World TB Day 2020

World TB Day falls on March 24th each year and commemorates the date in 1882 when Dr. Robert Koch announced the discovery of Mycobacterium tuberculosis, the cause of tuberculosis.

To mark World TB Day, Thorax and BMJ Open Respiratory Research have compiled a collection of the cutting edge research into tuberculosis that has been published in the journals in the last few years. All the papers collected here have been made free to read in order to advance the dissemination of TB research that is vital in the fight to eliminate tuberculosis.

Read more about World TB Day here and get involved in the conversation on Twitter; share your thoughts by using #ItsTimeToEndTB and #WorldTBDay and following @ThoraxBMJ and @BMJOpen_Resp.


Biomarkers of iron metabolism facilitate clinical diagnosis in Mycobacterium tuberculosis infection  
Youchao Dai, Wanshui Shan, Qianting Yang, et al.
Thorax Dec 2019, 74 (12) 1161-1167; DOI: 10.1136/thoraxjnl-2018-212557

Extensive global movement of multidrug-resistant M. tuberculosis strains revealed by whole-genome analysis
Keira A Cohen, Abigail L Manson, Thomas Abeel, et al.
Thorax Sep 2019, 74 (9) 882-889; DOI: 10.1136/thoraxjnl-2018-211616

Urban airborne particle exposure impairs human lung and blood Mycobacterium tuberculosis immunity
Martha Torres, Claudia Carranza, Srijata Sarkar, et al.
Thorax Jul 2019, 74 (7) 675-683; DOI: 10.1136/thoraxjnl-2018-212529

Predicting tuberculosis relapse in patients treated with the standard 6-month regimen: an individual patient data meta-analysis
Kamila Romanowski, Robert  Balshaw, Andrea Benedetti, et al.
Thorax Mar 2019, 74 (3) 291-297; DOI: 10.1136/thoraxjnl-2017-211120

Should NICE reconsider the 2016 UK guidelines on TB contact tracing? A cost-effectiveness analysis of contact investigations in London
Sean M Cavany, Emilia Vynnycky, Charlotte S Anderson, et al.
Thorax Feb 2019, 74 (2) 185-193; DOI: 10.1136/thoraxjnl-2018-211662

Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort
Charlotte Jackson, Jo Southern, Ajit Lalvani, et al.
Thorax Jan 2019, 74 (1) 91-94; DOI: 10.1136/thoraxjnl-2017-211124

Evaluating latent tuberculosis infection diagnostics using latent class analysis
Jason E Stout, Yanjue Wu, Christine S Ho, et al.
Thorax Nov 2018, 73 (11) 1062-1070; DOI: 10.1136/thoraxjnl-2018-211715

Reduction in tuberculosis incidence in the UK from 2011 to 2015: a population-based study
H Lucy Thomas, Ross J Harris, Morris C Muzyamba, et al.
Thorax Aug 2018, 73 (8) 769-775; DOI: 10.1136/thoraxjnl-2017-211074

High prevalence of TB disease in contacts of adults with extrapulmonary TB
Tom Wingfield, Peter MacPherson, Paul Cleary, L Peter Ormerod.
Thorax Aug 2018, 73 (8) 785-787; DOI: 10.1136/thoraxjnl-2017-210202

Trends in tuberculosis in the UK
Philippe Glaziou, Katherine Floyd, Mario Raviglione.
Thorax Aug 2018, 73 (8) 702-703; DOI: 10.1136/thoraxjnl-2018-211537

Stratification by interferon-γ release assay level predicts risk of incident TB
Brita Askeland Winje, Richard White, Heidi Syre, et al.
Thorax Jul 2018, 73 (7) 652-661; DOI: 10.1136/thoraxjnl-2017-211147

High prevalence of latent tuberculosis and bloodborne virus infection in a homeless population
Robert W Aldridge, Andrew C Hayward, Sara Hemming, et al.
Thorax Jun 2018, 73 (6) 557-564; DOI: 10.1136/thoraxjnl-2016-209579

Cytokine diagnosis of pleural TB: will it stand the test of time?
Marc Tebruegge, Paul T Elkington.
Thorax Mar 2018, 73 (3) 206-207; DOI: 10.1136/thoraxjnl-2017-210918

Screening contacts of patients with extrapulmonary TB for latent TB infection
Anna Humphreys, Aula Abbara, Sion Williams, et al.
Thorax Mar 2018, 73 (3) 277-278; DOI: 10.1136/thoraxjnl-2016-209639

Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis
Wen Wang, Qiong Zhou, Kan Zhai, et al.
Thorax Mar 2018, 73 (3) 240-247; DOI: 10.1136/thoraxjnl-2016-209718

Comorbidities, mortality and causes of death among patients with tuberculosis in Denmark 1998–2010: a nationwide, register-based case–control study
Andreas Fløe, Ole Hilberg, Christian Wejse, et al.
Thorax Jan 2018, 73 (1) 70-77; DOI: 10.1136/thoraxjnl-2016-209240

BMJ Open Respiratory Research

Presentation and healthcare delays among people with tuberculosis in London, and the impact on treatment outcome
Poppy Evenden, Anita Roche, Basel Karo, et al.
BMJ Open Respiratory Research Oct 2019, 6 (1) e000468; DOI: 10.1136/bmjresp-2019-000468

Monitoring tuberculosis contact tracing outcomes in Western Sydney, Australia
Laila Parvaresh, Shopna K Bag, Jin-Gun Cho, et al.
BMJ Open Respiratory Research Oct 2018, 5 (1) e000341; DOI: 10.1136/bmjresp-2018-000341

Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: a cluster randomised trial in Indian neonates vaccinated with BCG
Synne Jenum, Sumithra Selvam, Nelson Jesuraj, et al.
BMJ Open Respiratory Research Oct 2018, 5 (1) e000304; DOI: 10.1136/bmjresp-2018-000304

Initiation, scale-up and outcomes of the Cambodian National MDR-TB programme 2006–2016: hospital and community-based treatment through an NGO–NTP partnership
Sophan Sam, Adrienne Shapiro, Thim Sok, et al.
BMJ Open Respiratory Research Jun 2018, 5 (1) e000256; DOI: 10.1136/bmjresp-2017-000256

Alcohol drinking and cigarette smoking in relation to risk of active tuberculosis: prospective cohort study
Avril Zixin Soh, Cynthia Bin Eng Chee, Yee-Tang Wang, et al.
BMJ Open Respiratory Research Oct 2017, 4 (1) e000247; DOI: 10.1136/bmjresp-2017-000247

Post-tuberculous fibrosing mediastinitis: a review of the literature
Zhe Wu, Hannah Jarvis, Luke S Howard, et al.
BMJ Open Respiratory Research May 2017, 4 (1) e000174; DOI: 10.1136/bmjresp-2016-000174

Evaluation of prediagnosis emergency department presentations in patients with active tuberculosis: the role of chest radiography, risk factors and symptoms
S C Appleton, D W Connell, A Singanayagam, et al.
BMJ Open Respiratory Research Jan 2017, 4 (1) e000154; DOI: 10.1136/bmjresp-2016-000154

Images courtesy of U.S. Centers for Disease Control and Prevention, Division of Tuberculosis Elimination.