Acetylcholine acts as a neurotransmitter in the central and peripheral nervous systems in
humans. However, recent experiments demonstrate a widespread expression of the …

Tiotropium is commonly used in the treatment of chronic obstructive pulmonary disease.
Although largely considered to be a long-acting bronchodilator, its demonstrated efficacy in …

… Muscarinic agonists were shown to exert inhibitory effects on calcium activated potassium
channels (K ca ) and thereby oppose hyperpolarizing (ie, relaxant) stimuli. This effect involves …

Acetylcholine acts as a prominent transmitter in the central and peripheral nervous system.
The aim of the present study was to investigate whether mammalian non-neuronal cells can …

BACKGROUND:: The therapeutic value of secretolytic agents in COPD and asthma is still
disputed. For this reason, in a preclinical study we aimed to test the potential anti-inflammatory …

… Schw6rer H, Racks K, Kilbinger H. Effect of vasoactive intestinal polypeptide on the release
… Schw6rer H, Rack6 K. Effects of cisplatin on the release of 5-hydroxytryptamine from guinea-…

Rationale: Airway nitric oxide concentrations are reduced in cystic fibrosis (CF). Arginases
compete for L-arginine, the substrate of nitric oxide synthesis. Objectives: We hypothesized …

… Provided that the K m values and total activities of NO synthase and arginase are comparable,
the two enzymes may compete for the endogenous c-arginine, the availability of which …

Background and Purpose Artificial agonists may have higher efficacy for receptor activation
than the physiological agonist. Until now, such ‘superagonism’ has rarely been reported for …

Alveolar macrophages (AMΦ) exhibit arginase activity and may, in addition, express an
inducible form of nitric oxide (NO) synthase (iNOS). Both pathways may compete for the substrate…