Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Aging is a degenerative process associated with cumulative damage, which leads to cellular
dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also …

Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized
by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and …

Type 2 diabetes is characterized by insulin resistance and loss of β cell mass and function.
Aging is considered as a major risk factor for development of type 2 diabetes. However, the …

Mitochondrial dysfunction is a key feature of injury to numerous tissues and stem cell aging.
Although the tissue regenerative role of mesenchymal stem cell (MSC)-derived extracellular …

Aim This study aims to demonstrate the protective effects of monounsaturated oleic acid
(OA) against saturated palmitic acid (PA) induced cellular lipotoxicity in hepatocytes and rats …

Aims: Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial
dysfunction. As a major mechanism for cellular self-degradation, autophagy has been …

Background Pyroptosis is a novel programmed cell death. It is identified as caspase-1
dependent and characterized by plasma-membrane rupture and release of proinflammatory …

Senescence of bone marrow-derived mesenchymal stem cells (BMSCs) has been widely
reported to be closely correlated with aging-related diseases, including osteoporosis (OP) …

Macrophage polarization toward the M1 phenotype and its subsequent inflammatory
response have been implicated in the progression of diabetic complications. Despite …