Transgenic C. elegans as a model in Alzheimer's research

Y Wu, Y Luo - Current Alzheimer Research, 2005 - ingentaconnect.com
Alzheimer's disease (AD) has been associated with aggregation of β-amyloid peptide (Aβ)
and cell death in the brain. Using various models, such as the nematode Caenorhabditis …

Amyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans

Y Wu, Z Wu, P Butko, Y Christen… - Journal of …, 2006 - Soc Neuroscience
Amyloid-β (Aβ) toxicity has been postulated to initiate synaptic loss and subsequent
neuronal degeneration seen in Alzheimer's disease (AD). We previously demonstrated that …

EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease

F Tchantchou, Y Xu, Y Wu, Y Christen… - The FASEB …, 2007 - Wiley Online Library
ABSTRACT Standardized Ginkgo biloba extract EGb 761 exhibits beneficial effects to
patients with Alzheimer's disease (AD). It was previously demonstrated that EGb 761 inhibits …

[HTML][HTML] Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans

A Gutierrez-Zepeda, R Santell, Z Wu, M Brown… - BMC neuroscience, 2005 - Springer
Background Epidemiological studies have associated estrogen replacement therapy with a
lower risk of developing Alzheimer's disease, but a higher risk of developing breast cancer …

Evaluating latent tuberculosis infection diagnostics using latent class analysis

JE Stout, Y Wu, CS Ho, AC Pettit, PJ Feng, DJ Katz… - Thorax, 2018 - thorax.bmj.com
Background Lack of a gold standard for latent TB infection has precluded direct
measurement of test characteristics of the tuberculin skin test and interferon-γ release …

[HTML][HTML] Caenorhabditis elegans model for initial screening and mechanistic evaluation of potential new drugs for aging and Alzheimer's disease

Y Luo, Y Wu, M Brown, CD Link - Methods of Behavior Analysis in …, 2009 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is one of the most devastating CNS disorders of old age, which
has led to a serious public health problem. Currently about five million Americans are …

Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers

Y Wu, Z Cao, WL Klein, Y Luo - Neurobiology of aging, 2010 - Elsevier
Heat shock response, mediated by heat shock proteins, is a highly conserved physiological
process in multicellular organisms for reestablishment of cellular homeostasis. Expression of …

Serotonin regulation in a rat model of exercise-induced chronic fatigue

Z Liu, Y Wu, T Liu, R Li, M Xie - Neuroscience, 2017 - Elsevier
This study investigated the mechanisms underlying regulation of the serotonin system in the
rat brain during exercise-induced chronic fatigue. High-performance liquid chromatography …

Regulation of glioblastoma multiforme stem‐like cells by inhibitor of DNA binding proteins and oligodendroglial lineage‐associated transcription factors

Y Wu, JP Richard, SD Wang, P Rath, J Laterra… - Cancer …, 2012 - Wiley Online Library
Tumor‐initiating stem cells (also referred to as cancer stem cells, CSCs) are a subpopulation
of cancer cells that play unique roles in tumor propagation, therapeutic resistance and tumor …

Ginkgo biloba Extract EGb 761 and Wisconsin Ginseng Delay Sarcopenia in Caenorhabditis elegans

Z Cao, YJ Wu, K Curry, Z Wu… - The Journals of …, 2007 - academic.oup.com
Previously we reported that the standardized Ginkgo biloba extract EGb 761 extended life
span and increased stress resistance in Caenorhabditis elegans. In this study …