Significance of the microbiome in obstructive lung disease
The composition of the lung microbiome contributes to both health and disease, including
obstructive lung disease. Because it has been estimated that over 70% of the bacterial …
obstructive lung disease. Because it has been estimated that over 70% of the bacterial …
Gene-environment interactions in chronic inflammatory disease
H Renz, E Von Mutius, P Brandtzaeg, WO Cookson… - Nature …, 2011 - nature.com
Chronic inflammatory diseases represent a major challenge for both clinical research and
patient care, and evidence indicates that these disorders develop as a result of complex …
patient care, and evidence indicates that these disorders develop as a result of complex …
Merlin—rapid analysis of dense genetic maps using sparse gene flow trees
Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP)
maps will produce data sets that exceed the limitations of current computational tools. Here …
maps will produce data sets that exceed the limitations of current computational tools. Here …
[HTML][HTML] Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
Background The study of microbial communities has been revolutionised in recent years by
the widespread adoption of culture independent analytical techniques such as 16S rRNA …
the widespread adoption of culture independent analytical techniques such as 16S rRNA …
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We
carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …
carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Approaches exploiting trait distribution extremes may be used to identify loci associated with
common traits, but it is unknown whether these loci are generalizable to the broader …
common traits, but it is unknown whether these loci are generalizable to the broader …
Genetic and perinatal risk factors for asthma onset and severity: a review and theoretical analysis
MB Bracken, K Belanger, WO Cookson… - Epidemiologic …, 2002 - academic.oup.com
Asthma is a major chronic disease, and several studies indicate that it is on the rise
worldwide (1). A recent report (2) from the Centers for Disease Control and Prevention …
worldwide (1). A recent report (2) from the Centers for Disease Control and Prevention …
Genome-wide genetic association of complex traits in heterogeneous stock mice
Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress
in the molecular dissection of complex traits in mice. Here we show that genome-wide high …
in the molecular dissection of complex traits in mice. Here we show that genome-wide high …
Seventy-five genetic loci influencing the human red blood cell
P Van Der Harst, W Zhang, I Mateo Leach, A Rendon… - Nature, 2012 - nature.com
Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …
growth retardation and impaired physical capacity. To understand further the genetic factors …
Genetic and environmental effects on complex traits in mice
The interaction between genotype and environment is recognized as an important source of
experimental variation when complex traits are measured in the mouse, but the magnitude …
experimental variation when complex traits are measured in the mouse, but the magnitude …