Idiopathic pulmonary fibrosis (IPF) is an incurable complex genetic disorder that is
associated with sequence changes in 7 genes (MUC5B, TERT, TERC, RTEL1, PARN …

The interest in performing gene–environment interaction studies has seen a significant
increase with the increase of advanced molecular genetics techniques. Practically, it …

Background The mutations that have been implicated in pulmonary fibrosis account for only
a small proportion of the population risk. Methods Using a genomewide linkage scan, we …

Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown. The age-related acquisition of …

We performed a genome-wide association study of non-Hispanic, white individuals with
fibrotic idiopathic interstitial pneumonias (IIPs; n= 1,616) and controls (n= 4,683), with follow …

Sarcoidosis is a multisystem, T-helper 1 (Th1) cell biased granulomatous disorder that
develops in genetically predisposed individuals who are exposed to yet unknown …

Importance Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF),
which are based on clinical and physiological parameters, have modest value in predicting …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …