[HTML][HTML] Supersulphides provide airway protection in viral and chronic lung diseases
T Matsunaga, H Sano, K Takita, M Morita… - Nature …, 2023 - nature.com
Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …
A novel development of sarcoidosis following covid-19 vaccination and a literature review
T Numakura, K Murakami, T Tamada… - Internal …, 2022 - jstage.jst.go.jp
BNT162b2 (Pfizer/BioNTech) is a coronavirus disease 2019 (COVID-19) vaccine containing
nucleosidemodified messenger RNA encoding the severe acute respiratory syndrome …
nucleosidemodified messenger RNA encoding the severe acute respiratory syndrome …
Production of reactive persulfide species in chronic obstructive pulmonary disease
T Numakura, H Sugiura, T Akaike, T Ida, S Fujii… - Thorax, 2017 - thorax.bmj.com
Background Oxidative stress is a major aetiological factor driving chronic obstructive
pulmonary disease (COPD). Recently recognised as potent antioxidants, reactive persulfide …
pulmonary disease (COPD). Recently recognised as potent antioxidants, reactive persulfide …
[HTML][HTML] Oxidative stress enhances the expression of IL-33 in human airway epithelial cells
H Aizawa, A Koarai, Y Shishikura, S Yanagisawa… - Respiratory …, 2018 - Springer
Abstract Background Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its
possible involvement in the pathophysiology of COPD and viral-induced exacerbations has …
possible involvement in the pathophysiology of COPD and viral-induced exacerbations has …
[HTML][HTML] Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator
Lung function reflects the ability of the respiratory system and is utilized for the assessment
of respiratory diseases. Because type 2 airway inflammation influences lung function …
of respiratory diseases. Because type 2 airway inflammation influences lung function …
Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease
K Onodera, H Sugiura, M Yamada, A Koarai, N Fujino… - Thorax, 2017 - thorax.bmj.com
Rationale Cellular senescence is observed in the lungs of patients with COPD and may
contribute to the disease pathogenesis. Growth differentiation factor 11 (GDF11) belongs to …
contribute to the disease pathogenesis. Growth differentiation factor 11 (GDF11) belongs to …
Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis
S Ohkouchi, M Kanehira, D Saigusa, M Ono… - American Journal of …, 2022 - atsjournals.org
As shown in our previous studies, the intratracheal-administration of STC1 (stanniocalcin-1)
ameliorates pulmonary fibrosis by reducing oxidative and endoplasmic reticulum stress …
ameliorates pulmonary fibrosis by reducing oxidative and endoplasmic reticulum stress …
Nitrosative stress in patients with asthma–chronic obstructive pulmonary disease overlap
Y Kyogoku, H Sugiura, T Ichikawa, T Numakura… - Journal of Allergy and …, 2019 - Elsevier
Background Asthma–chronic obstructive pulmonary disease overlap (ACO) has frequent
exacerbations and a poor quality of life and prognosis compared with those of chronic …
exacerbations and a poor quality of life and prognosis compared with those of chronic …
[HTML][HTML] Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium
Y Shishikura, A Koarai, H Aizawa, M Yamaya… - Respiratory …, 2016 - Springer
Background In response to tissue damage or inflammation, adenosine-5′-triphosphate
(ATP) is released into the extracellular compartment and has been demonstrated to …
(ATP) is released into the extracellular compartment and has been demonstrated to …
[HTML][HTML] PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite
T Saito, T Ichikawa, T Numakura, M Yamada… - Respiratory …, 2021 - Springer
Background The airway epithelial barrier function is disrupted in the airways of asthmatic
patients. Abnormal mitochondrial biogenesis is reportedly involved in the pathogenesis of …
patients. Abnormal mitochondrial biogenesis is reportedly involved in the pathogenesis of …