A role for ghrelin in the central regulation of feeding

M Nakazato, N Murakami, Y Date, M Kojima, H Matsuo… - Nature, 2001 - nature.com
Ghrelin is an acylated peptide that stimulates the release of growth hormone from the
pituitary. Ghrelin-producing neurons are located in the hypothalamus, whereas ghrelin …

Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans

Y Date, M Kojima, H Hosoda, A Sawaguchi… - …, 2000 - academic.oup.com
Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It
stimulated the release of GH from the anterior pituitary through the GH secretagogue …

Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion

T Shiiya, M Nakazato, M Mizuta, Y Date… - The Journal of …, 2002 - academic.oup.com
Ghrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food
intake and GH secretion. We determined plasma ghrelin concentrations in patients with …

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

Y Date, N Murakami, K Toshinai, S Matsukura… - Gastroenterology, 2002 - Elsevier
Background & Aims: Visceral sensory information is transmitted to the brain through the
afferent vagus nerve. Ghrelin, a peptide primarily produced in the stomach, stimulates both …

Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration

K Toshinai, MS Mondal, M Nakazato, Y Date… - Biochemical and …, 2001 - Elsevier
Ghrelin is a novel gut–brain peptide that binds to the growth hormone secretagogue
receptor (GHS-R), thereby functioning in the regulation of growth hormone (GH) release and …

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Y Date, Y Ueta, H Yamashita… - Proceedings of the …, 1999 - National Acad Sciences
We determined the immunohistochemical distributions of orexin-A and orexin-B,
hypothalamic peptides that function in the regulation of feeding behavior and energy …

Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion

Y Date, M Nakazato, S Hashiguchi, K Dezaki… - Diabetes, 2002 - Am Diabetes Assoc
Ghrelin, a novel growth hormone–releasing peptide isolated from human and rat stomach, is
a 28–amino acid peptide with a posttranslational acylation modification that is indispensable …

Ghrelin-induced food intake is mediated via the orexin pathway

K Toshinai, Y Date, N Murakami, M Shimada… - …, 2003 - academic.oup.com
The hypothalamus regulates energy intake by integrating the degree of starvation or
satiation with the status of the environment through a variety of neuronal and blood-derived …

Sympathetic and cardiovascular actions of orexins in conscious rats

T Shirasaka, M Nakazato… - American Journal …, 1999 - journals.physiology.org
The novel hypothalamic peptides orexin-A and orexin-B are known to induce feeding
behavior when administered intracerebroventricularly, but little is known about other …

Ghrelin acts in the central nervous system to stimulate gastric acid secretion

Y Date, M Nakazato, N Murakami, M Kojima… - Biochemical and …, 2001 - Elsevier
Ghrelin is a novel acylated peptide that functions in the regulation of growth hormone
release and energy metabolism. It was isolated from rat stomach as an endogenous ligand …