[HTML][HTML] Clinical review: Ventilator-induced diaphragmatic dysfunction-human studies confirm animal model findings!

S Jaber, B Jung, S Matecki, BJ Petrof - Critical care, 2011 - Springer
Diaphragmatic function is a major determinant of the ability to successfully wean patients
from mechanical ventilation. However, the use of controlled mechanical ventilation in animal …

Ventilator-induced diaphragmatic dysfunction

BJ Petrof, S Jaber, S Matecki - Current opinion in critical care, 2010 - journals.lww.com
Diaphragmatic dysfunction is common in mechanically ventilated patients and is a likely
cause of weaning failure. Recently, there has been a great expansion in our knowledge of …

Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans

…, A Lacampagne, A Philips, S Matecki - American journal of …, 2011 - atsjournals.org
Rationale: Diaphragmatic function is a major determinant of the ability to successfully wean
patients from mechanical ventilation (MV). Paradoxically, MV itself results in a rapid loss of …

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

…, C Carlson, M Mongillo, X Liu, L Rothman, S Matecki… - Nature medicine, 2009 - nature.com
Duchenne muscular dystrophy is characterized by progressive muscle weakness and early
death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large …

Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact—a prospective study

…, G Chanques, C Coirault, S Matecki… - American journal of …, 2013 - atsjournals.org
Rationale: Diaphragmatic insults occurring during intensive care unit (ICU) stays have
become the focus of intense research. However, diaphragmatic abnormalities at the initial …

Mechanical ventilation–induced diaphragm disuse in humans triggers autophagy

…, P Metrakos, G Danialou, S Matecki… - American journal of …, 2010 - atsjournals.org
Rationale: Controlled mechanical ventilation (CMV) results in atrophy of the human
diaphragm. The autophagy-lysosome pathway (ALP) contributes to skeletal muscle …

Post-extubation stridor in intensive care unit patients: Risk factors evaluation and importance of the cuff-leak test

S Jaber, G Chanques, S Matecki, M Ramonatxo… - Intensive care …, 2003 - Springer
Objective. To evaluate the incidence and identify factors associated with the occurrence of
post-extubation stridor and to evaluate the performance of the cuff-leak test in detecting this …

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

…, C Cassan, S Richard, S Matecki… - Proceedings of the …, 2010 - National Acad Sciences
Patients with Duchenne muscular dystrophy (DMD) have a progressive dilated
cardiomyopathy associated with fatal cardiac arrhythmias. Electrical and functional …

Is treatment with a high flow nasal cannula effective in acute viral bronchiolitis? A physiologic study

C Milési, J Baleine, S Matecki, S Durand… - Intensive care …, 2013 - Springer
Purpose The high flow nasal cannula (HFNC) has recently been proposed to support infants
with respiratory syncytial virus (RSV)-related respiratory distress. However, in this disease …

Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation

…, R Chaturvedi, K Rygiel, S Matecki… - American journal of …, 2012 - atsjournals.org
Rationale: Mechanical ventilation (MV) is associated with adverse effects on the diaphragm,
but the cellular basis for this phenomenon, referred to as ventilator-induced diaphragmatic …