User profiles for "author:S Holgate"
Stephen HolgateUniversity of Southampton, Faculty of Medicine Verified email at soton.ac.uk Cited by 152738 |
Air pollution and health
B Brunekreef, ST Holgate - The lancet, 2002 - thelancet.com
The health effects of air pollution have been subject to intense study in recent years.
Exposure to pollutants such as airborne participate matter and ozone has been associated …
Exposure to pollutants such as airborne participate matter and ozone has been associated …
Mucosal inflammation in Asthma1. 2
Asthma can be considered a combination of three features: airways obstruction with
spontaneous and pharmacologic reversibility, increased airways responsiveness to …
spontaneous and pharmacologic reversibility, increased airways responsiveness to …
Innate and adaptive immune responses in asthma
ST Holgate - Nature medicine, 2012 - nature.com
The recognition that asthma is primarily an inflammatory disorder of the airways associated
with T helper type 2 (TH2) cell-dependent promotion of IgE production and recruitment of …
with T helper type 2 (TH2) cell-dependent promotion of IgE production and recruitment of …
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
SL Johnston, PK Pattemore, G Sanderson, S Smith… - Bmj, 1995 - bmj.com
Objective: To study the association between upper and lower respiratory viral infections and
acute exacerbations of asthma in schoolchildren in the community. Design: Community …
acute exacerbations of asthma in schoolchildren in the community. Design: Community …
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing,
wheezing and breathlessness. Although environmental factors such as allergen exposure …
wheezing and breathlessness. Although environmental factors such as allergen exposure …
[HTML][HTML] Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0
Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …
accurate reporting is vital to this process; it allows readers to assess the reliability of the …
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects
are more susceptible to these infections. To investigate the underlying mechanisms of this …
are more susceptible to these infections. To investigate the underlying mechanisms of this …
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
MJ Leckie, A ten Brinke, J Khan, Z Diamant… - The Lancet, 2000 - thelancet.com
Summary Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which
are thought to have a major role in the pathogenesis of asthma and other allergic diseases …
are thought to have a major role in the pathogenesis of asthma and other allergic diseases …
[HTML][HTML] Exposure to House-Dust Mite Allergen (Der p I) and the Development of Asthma in Childhood: A Prospective Study
R Sporik, ST Holgate, TAE Platts-Mills… - New England journal …, 1990 - Mass Medical Soc
Abstract Background and Methods. Children with asthma commonly have positive skin tests
for inhaled allergens, and in the United Kingdom the majority of older children with asthma …
for inhaled allergens, and in the United Kingdom the majority of older children with asthma …