The application of physiologically based pharmacokinetic (PBPK) modeling has developed
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …

This work provides a perspective on the qualification and verification of physiologically
based pharmacokinetic (PBPK) platforms/models intended for regulatory submission based …

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous
disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes …

The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a
single colony isolate of strain NCIMB8826 that was originally isolated from human saliva …

Importance The prevalence of cardiometabolic multimorbidity is increasing. Objective To
estimate reductions in life expectancy associated with cardiometabolic multimorbidity …

Purpose: To prospectively compare 16-section multidetector computed tomography (CT) at
100 and 120 kVp for image quality and radiation dose. Materials and Methods: The study …

Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated
with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly …

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations The first book
dedicated to the emerging field of physiologically based pharmacokinetic modeling (PBPK) …

Mutations in the filamin C gene (FLNC) cause a myofibrillar myopathy (MFM),
morphologically characterized by focal myofibrillar destruction and abnormal accumulation …

Use is a major factor driving plasticity of cortical processing and cortical maps. As
demonstrated of blind Braille readers and musicians, long-lasting and exceptional usage of …