Rationale: Heterogeneity in asthma expression is multidimensional, including variability in
clinical, physiologic, and pathologic parameters. Classification requires consideration of …

Background Treatment decisions in asthma are based on assessments of symptoms and
simple measures of lung function, which do not relate closely to underlying eosinophilic …

Background Exacerbations of asthma are associated with substantial morbidity and mortality
and with considerable use of health care resources. Preventing exacerbations remains an …

The reclassification of asthma based on subphenotypes : Current Opinion in Allergy and
Clinical Immunology The reclassification of asthma based on subphenotypes : Current Opinion …

Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) are
heterogeneous with respect to inflammation and etiology. Objectives: Investigate biomarker …

Background: The debate as to whether asthma is a single or heterogeneous disease
remains unresolved although pathological studies, mostly using fibreoptic bronchoscopy on …

Background The development of tumor necrosis factor α (TNF-α) antagonists has made it
feasible to investigate the role of this cytokine in refractory asthma. Methods We measured …

Rationale: Current asthma guidelines recommend adjusting antiinflammatory treatment on
the basis of the results of lung function tests and symptom assessment, neither of which are …

Purpose The role played by the innate immune system in determining survival from non–
small-cell lung cancer (NSCLC) is unclear. The aim of this study was to investigate the …

Rationale: The importance of Aspergillus fumigatus sensitization and colonization of the
airways in patients with asthma is unclear. Objectives: To define the relationship between …