Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death
worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by …

Chronic obstructive pulmonary disease (COPD) is associated with features of accelerated
aging, including cellular senescence, DNA damage, oxidative stress, and extracellular …

COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation
can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP) …

Introduction COPD is a chronic, progressive, inflammatory disease of the lungs and the third
leading cause of death worldwide. The current knowledge of the pathophysiology of COPD …

Vacuole membrane protein (VMP1) is a putative autophagy protein, which together with
Beclin-1 acts as a molecular switch in activating autophagy. In the present study the role of …

Abstract Knowledge on age-related miRNA changes in healthy individuals and their
interaction with mRNAs is lacking. We studied age-related mRNA and miRNA expression …

Rationale In COPD, small airway fibrosis occurs due to increased extracellular matrix (ECM)
deposition in and around the airway smooth muscle (ASM) layer. Studies of immune cells …

Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary
disease (COPD). The exact mechanisms are unknown and comprehensive analysis …

Background: Lung fibroblasts from Severe Early-Onset (SEO-) COPD patients exhibit
increased cellular senescence with higher levels of senescence-associated secretory …

Rationale: Higher levels of senescence have been demonstrated in COPD patients,
including severe early onset (SEO)-COPD. Recently we demonstrated a link between …