Preschool multiple-breath washout testing. An official American Thoracic Society technical statement
PD Robinson, P Latzin, KA Ramsey… - American journal of …, 2018 - atsjournals.org
Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial
tree, although the extent to which this occurs can vary among conditions. The multiple …
tree, although the extent to which this occurs can vary among conditions. The multiple …
Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function
R Amin, P Subbarao, A Jabar, S Balkovec, R Jensen… - Thorax, 2010 - thorax.bmj.com
Background and aims Sensitive outcome measures to assess the efficacy of therapeutic
interventions in patients with cystic fibrosis (CF) with mild lung disease are currently lacking …
interventions in patients with cystic fibrosis (CF) with mild lung disease are currently lacking …
Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis. A pilot study using inhaled hypertonic saline
P Subbarao, S Stanojevic, M Brown… - American journal of …, 2013 - atsjournals.org
Rationale: Lung clearance index (LCI), measured by multiple breath washout (MBW), is a
noninvasive measure of ventilation inhomogeneity that holds promise as an objective …
noninvasive measure of ventilation inhomogeneity that holds promise as an objective …
Progression of lung disease in preschool patients with cystic fibrosis
S Stanojevic, SD Davis, G Retsch-Bogart… - American journal of …, 2017 - atsjournals.org
Rationale: Implementation of intervention strategies to prevent lung damage in early cystic
fibrosis (CF) requires objective outcome measures that capture and track lung disease …
fibrosis (CF) requires objective outcome measures that capture and track lung disease …
Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial
Background Inhaled hypertonic saline enhances mucociliary clearance, improves lung
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age …
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age …
Normative data for multiple breath washout outcomes in school-aged Caucasian children
P Anagnostopoulou, P Latzin, R Jensen… - European …, 2020 - Eur Respiratory Soc
Background The multiple breath nitrogen washout (N2MBW) technique is increasingly used
to assess the degree of ventilation inhomogeneity in school-aged children with lung …
to assess the degree of ventilation inhomogeneity in school-aged children with lung …
[HTML][HTML] Multiple breath nitrogen washout: a feasible alternative to mass spectrometry
R Jensen, S Stanojevic, K Gibney, JG Salazar… - PloS one, 2013 - journals.plos.org
Background The lung clearance index (LCI), measured by multiple breath washout (MBW),
reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis …
reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis …
The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled …
HAWM Tiddens, Y Chen, ER Andrinopoulou… - The lancet Respiratory …, 2022 - thelancet.com
Summary Background In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7%
hypertonic saline improved the lung clearance index in children aged 3–6 years with cystic …
hypertonic saline improved the lung clearance index in children aged 3–6 years with cystic …
Lung clearance index to track acute respiratory events in school-age children with cystic fibrosis
L Perrem, S Stanojevic, M Shaw, R Jensen… - American Journal of …, 2021 - atsjournals.org
Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in
preschool children with cystic fibrosis (CF), but its utility to identify and manage these events …
preschool children with cystic fibrosis (CF), but its utility to identify and manage these events …
[HTML][HTML] A systematic approach to multiple breath nitrogen washout test quality
Background Accurate estimates of multiple breath washout (MBW) outcomes require correct
operation of the device, appropriate distraction of the subject to ensure they breathe in a …
operation of the device, appropriate distraction of the subject to ensure they breathe in a …