Preschool multiple-breath washout testing. An official American Thoracic Society technical statement

PD Robinson, P Latzin, KA Ramsey… - American journal of …, 2018 - atsjournals.org
Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial
tree, although the extent to which this occurs can vary among conditions. The multiple …

Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function

R Amin, P Subbarao, A Jabar, S Balkovec, R Jensen… - Thorax, 2010 - thorax.bmj.com
Background and aims Sensitive outcome measures to assess the efficacy of therapeutic
interventions in patients with cystic fibrosis (CF) with mild lung disease are currently lacking …

Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis. A pilot study using inhaled hypertonic saline

P Subbarao, S Stanojevic, M Brown… - American journal of …, 2013 - atsjournals.org
Rationale: Lung clearance index (LCI), measured by multiple breath washout (MBW), is a
noninvasive measure of ventilation inhomogeneity that holds promise as an objective …

Progression of lung disease in preschool patients with cystic fibrosis

S Stanojevic, SD Davis, G Retsch-Bogart… - American journal of …, 2017 - atsjournals.org
Rationale: Implementation of intervention strategies to prevent lung damage in early cystic
fibrosis (CF) requires objective outcome measures that capture and track lung disease …

Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial

F Ratjen, SD Davis, S Stanojevic… - The lancet Respiratory …, 2019 - thelancet.com
Background Inhaled hypertonic saline enhances mucociliary clearance, improves lung
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age …

Normative data for multiple breath washout outcomes in school-aged Caucasian children

P Anagnostopoulou, P Latzin, R Jensen… - European …, 2020 - Eur Respiratory Soc
Background The multiple breath nitrogen washout (N2MBW) technique is increasingly used
to assess the degree of ventilation inhomogeneity in school-aged children with lung …

[HTML][HTML] Multiple breath nitrogen washout: a feasible alternative to mass spectrometry

R Jensen, S Stanojevic, K Gibney, JG Salazar… - PloS one, 2013 - journals.plos.org
Background The lung clearance index (LCI), measured by multiple breath washout (MBW),
reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis …

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled …

HAWM Tiddens, Y Chen, ER Andrinopoulou… - The lancet Respiratory …, 2022 - thelancet.com
Summary Background In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7%
hypertonic saline improved the lung clearance index in children aged 3–6 years with cystic …

Lung clearance index to track acute respiratory events in school-age children with cystic fibrosis

L Perrem, S Stanojevic, M Shaw, R Jensen… - American Journal of …, 2021 - atsjournals.org
Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in
preschool children with cystic fibrosis (CF), but its utility to identify and manage these events …

[HTML][HTML] A systematic approach to multiple breath nitrogen washout test quality

R Jensen, S Stanojevic, M Klingel, ME Pizarro, GL Hall… - PloS one, 2016 - journals.plos.org
Background Accurate estimates of multiple breath washout (MBW) outcomes require correct
operation of the device, appropriate distraction of the subject to ensure they breathe in a …