Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations
CS Berenson, RL Kruzel, E Eberhardt, R Dolnick… - Thorax, 2014 - thorax.bmj.com
Background Alveolar macrophages (AM) in COPD have fundamentally impaired
responsiveness to Toll-like receptor 2 (TLR2) and TLR4 ligands of non-typeable …
responsiveness to Toll-like receptor 2 (TLR2) and TLR4 ligands of non-typeable …
Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers
CC Hong, S Yao, SE McCann, RY Dolnick… - Breast cancer research …, 2013 - Springer
Immune signatures in breast tumors differ by estrogen receptor (ER) status. The purpose of
this study was to assess associations between ER phenotypes and circulating levels of …
this study was to assess associations between ER phenotypes and circulating levels of …
Development of a novel antibody–drug conjugate for the potential treatment of ovarian, lung, and renal cell carcinoma expressing TIM-1
LJ Thomas, L Vitale, T O'Neill, RY Dolnick… - Molecular Cancer …, 2016 - AACR
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a type I transmembrane protein that
was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression …
was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression …
A novel function for the rTS gene
BJ Dolnick, NJ Angelino, R Dolnick… - Cancer biology & …, 2003 - Taylor & Francis
The rTS gene codes for a naturally occurring antisense RNA to thymidylate synthase (TS)
mRNA and two proteins (rTSa and rTSβ). The role of the major protein product of rTS, rTβ …
mRNA and two proteins (rTSa and rTSβ). The role of the major protein product of rTS, rTβ …
Enhancement of 5-Fluorouracil Sensitivity by an rTS Signaling Mimic in H630 Colon Cancer Cells
R Dolnick, Q Wu, NJ Angelino, LV Stephanie, KC Chow… - Cancer Research, 2005 - AACR
The rTSβ protein has been hypothesized to synthesize signaling molecules that can down-
regulate thymidylate synthase. These molecules share biological and chemical properties …
regulate thymidylate synthase. These molecules share biological and chemical properties …
Developing vestibular ganglion neurons switch trophic sensitivity from BDNF to GDNF after target innervation
E Hashino, RY Dolnick, CS Cohan - Journal of neurobiology, 1999 - Wiley Online Library
Recent evidence showing a distinctive cell loss in vestibular and cochlear ganglia of brain‐
derived neurotrophic factor (BDNF) versus neurotrophin‐3 (NT‐3) null mutant mice …
derived neurotrophic factor (BDNF) versus neurotrophin‐3 (NT‐3) null mutant mice …
Developmental changes in growth factors released by the embryonic inner ear
LM Bianchi, R Dolnick, A Medd, CS Cohan - Experimental neurology, 1998 - Elsevier
Recent studies have demonstrated a role for neurotrophins in regulating the survival of
developing auditory and vestibular neurons. However, the developmental time-course for …
developing auditory and vestibular neurons. However, the developmental time-course for …
Pretreatment levels of circulating Th1 and Th2 cytokines and their ratios are associated with ER-negative and triple-negative breast cancers.
CC Hong, S Yao, S McCann, RY Dolnick… - … Biomarkers & Prevention, 2012 - AACR
Purpose: Immune signatures differ between estrogen receptor negative (ER−) and ER
positive (ER+) breast tumors. The purpose of this study was to assess associations between …
positive (ER+) breast tumors. The purpose of this study was to assess associations between …
Development of an antibody-drug conjugate targeting TIM-1 for the treatment of ovarian and renal cell carcinoma
LJ Thomas, L Vitale, T O'Neill, R Dolnick, PK Wallace… - Cancer Research, 2014 - AACR
T cell immunoglobulin and mucin domain 1 (TIM-1) is a type I transmembrane protein that
was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression …
was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression …
Improving the stability and efficacy of rTS mimetic OHL
J Wang, Y Xin, L Chen, D Lu, MG Wientjes, B Dolnick… - Cancer Research, 2007 - AACR
Abstract 1411 OHL (3-oxododecanoyl homoserine lactone, or 3-oxo-C12-HSL) has rTS
mimetic activity, affects the cytoskeleton of human cancer cells, down-regulates the …
mimetic activity, affects the cytoskeleton of human cancer cells, down-regulates the …