Hepatitis B virus genome variability and disease progression: the impact of pre-core mutants and HBV genotypes

M Buti, F Rodriguez-Frias, R Jardi, R Esteban - Journal of clinical virology, 2005 - Elsevier
The hepatitis B virus (HBV), a member of the Hepadnaviridae family, is prone to mutations
due to its asymmetric replication via reverse transcription of an RNA intermediate. The …

Role of hepatitis B, C, and D viruses in dual and triple infection: influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral …

R Jardi, F Rodriguez, M Buti, X Costa, M Cotrina… - Hepatology, 2001 - Elsevier
The interactions among hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta
virus (HDV) were studied by measuring HBV-DNA and HCV-RNA levels and by determining …

Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D

M Schaper, F Rodriguez-Frias, R Jardi, D Tabernero… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: This study presents a real-time reverse-transcription PCR (rt-RT-
PCR) assay for hepatitis delta virus (HDV) RNA quantification, designed to clarify the …

Long-term immunogenicity and efficacy of hepatitis B vaccine in hemodialysis patients

M Buti, L Viladomiu, R Jardi, A Olmos… - American journal of …, 1992 - karger.com
Although the efficacy of hepatitis B vaccines in patients under chronic hemodialysis
treatment has been well documented, the persistence of immunity in this population remains …

Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations

F Rodriguez-Frias, M Buti, R Jardi, M Cotrina… - Hepatology, 1995 - Elsevier
The precore-core gene of hepatitis B virus (HBV) was directly sequenced from serum
samples of 42 patients with chronic B hepatitis (19 hepatitis B e antigen [HBeAg]+ and 23 …

Adherence to Lamivudine after an early withdrawal of hepatitis B immune globulin plays an important role in the long-term prevention of hepatitis B virus recurrence

M Buti, A Mas, M Prieto, F Casafont, A González… - …, 2007 - journals.lww.com
Lamivudine combined with hepatitis B immune globulin (HBIg) is the standard of care for
preventing the recurrence hepatitis B virus after liver transplant. To determine the risk of …

Rare alpha-1-antitrypsin variants: are they really so rare?

F Rodriguez-Frias, M Miravitlles… - Therapeutic …, 2012 - journals.sagepub.com
Alpha-1-antitrypsin (α1-AT) deficiency is mainly evaluated in the diagnostic process of
chronic obstructive pulmonary disease (COPD). Around 95% of individuals with severe α1 …

Rapid Screening for α1-Antitrypsin Deficiency in Patients with Chronic Obstructive Pulmonary Disease Using Dried Blood Specimens

F Rodriguez, R Jardí, X Costa, M Cotrina… - American journal of …, 2002 - atsjournals.org
We describe two reliable methods for high-throughput screening of proteinase inhibitor (PI)
S and PI Z α1-antitrypsin (α1-AT) deficiency alleles from dried blood spot (DBS) specimens …

Glutathione S-transferase P1 and lung function in patients with α1-antitrypsin deficiency and COPD

F Rodriguez, C de la Roza, R Jardi, M Schaper, R Vidal… - Chest, 2005 - Elsevier
Background The glutathione S-transferase P1 (GSTP1) gene is involved in detoxification of
electrophilic substances of tobacco smoke. A polymorphism at nucleotide 315 of this gene …

Is hepatitis B virus subtype testing useful in predicting virological response and resistance to lamivudine?

M Buti, M Cotrina, A Valdes, R Jardi… - Journal of …, 2002 - journal-of-hepatology.eu
To the Editor: The introduction of lamivudine in the therapy of chronic hepatitis B represents
a major advance in the treatment of this disease, especially in patients intolerant or resistant …