CD4+ CD25+ regulatory T cells (Treg) play a central role in the prevention of autoimmunity
and in the control of immune responses by down-regulating the function of effector CD4+ or …

Tuberculosis (TB) remains a serious global public health problem in the present. TB also
affects other sites (extrapulmonary tuberculosis, EPTB), and accounts for a significant …

Background Complement functions as an important host defense system and complement
C5 and C7 have been implicated in immunopathology of tuberculosis. However, little is …

Gamma interferon (IFN-γ) release assays have been proven to be useful in the diagnosis of
Mycobacterium tuberculosis infection. Nevertheless, their specificity and sensitivity vary …

IL-22 has been suggested to play an important role in immune response against
Mycobacterium tuberculosis infection. However, the exact role of IL-22 in human …

Aims A high proportion of all patients with tuberculosis (TB) present with extrapulmonary TB
(EPTB), including concurrent EPTB involving more than one extrapulmonary lesion site …

Diagnosis of tuberculous pleurisy remains a challenge in the clinic. In this study, we
evaluated the usefulness of a previously developed Mycobacterium tuberculosis antigen …

Background Biomarker-based tests for diagnosing TB currently rely on detecting
Mycobacterium tuberculosis (Mtb) antigen-specific cellular responses. While this approach …

The physiological functions of macrophage, which plays a central role in the pathogenesis of
tuberculosis, depend on its redox state. System xc-, a cystine-glutamate transporter, which …

We performed a multicenter, prospective, randomized study to investigate the efficacy and
safety of clofazimine (CLO) for treatment of extensively drug-resistant tuberculosis (XDR-TB) …