Human asthma phenotypes: from the clinic, to cytokines, and back again
NR Bhakta, PG Woodruff - Immunological reviews, 2011 - Wiley Online Library
A large body of experimental evidence supports the hypothesis that T‐helper 2 (Th2)
cytokines orchestrate allergic airway inflammation in animal models. However, human …
cytokines orchestrate allergic airway inflammation in animal models. However, human …
Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management
Chronic obstructive pulmonary disease (COPD) is a common, complex, and heterogeneous
disorder that is responsible for substantial and growing morbidity, mortality, and health-care …
disorder that is responsible for substantial and growing morbidity, mortality, and health-care …
[PDF][PDF] The extracellular RNA communication consortium: establishing foundational knowledge and technologies for extracellular RNA research
S Das, AB Abdel-Mageed, C Adamidi, PD Adelson… - Cell, 2019 - cell.com
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate
progress in the new field of extracellular RNA (exRNA) biology and to establish whether …
progress in the new field of extracellular RNA (exRNA) biology and to establish whether …
T-helper type 2–driven inflammation defines major subphenotypes of asthma
PG Woodruff, B Modrek, DF Choy, G Jia… - American journal of …, 2009 - atsjournals.org
Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is
considered the central molecular mechanism underlying asthma, and Th2 cytokines are …
considered the central molecular mechanism underlying asthma, and Th2 cytokines are …
[HTML][HTML] Azithromycin for prevention of exacerbations of COPD
RK Albert, J Connett, WC Bailey… - … England Journal of …, 2011 - Mass Medical Soc
Background Acute exacerbations adversely affect patients with chronic obstructive
pulmonary disease (COPD). Macrolide antibiotics benefit patients with a variety of …
pulmonary disease (COPD). Macrolide antibiotics benefit patients with a variety of …
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
PG Woodruff, HA Boushey… - Proceedings of the …, 2007 - National Acad Sciences
Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and
other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute …
other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute …
Muc5b is required for airway defence
MG Roy, A Livraghi-Butrico, AA Fletcher, MM McElwee… - Nature, 2014 - nature.com
Respiratory surfaces are exposed to billions of particulates and pathogens daily. A
protective mucus barrier traps and eliminates them through mucociliary clearance (MCC) …
protective mucus barrier traps and eliminates them through mucociliary clearance (MCC) …
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
G Jia, RW Erickson, DF Choy, S Mosesova… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …
We recently described a distinct subtype of asthma defined by the expression of genes …
[HTML][HTML] Clinical significance of symptoms in smokers with preserved pulmonary function
PG Woodruff, RG Barr, E Bleecker… - … England Journal of …, 2016 - Mass Medical Soc
Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) …
requires a ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) …
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19
MGP van der Wijst, SE Vazquez… - Science translational …, 2021 - science.org
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some
patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe …
patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe …