Tuberculosis (TB) remains a global health pandemic. Infection is spread by the aerosol route
and Mycobacterium tuberculosis must drive lung destruction to be transmitted to new hosts …

Immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment. However, immune-
related adverse events (irAEs) are a common side effect which can mimic infection …

The extracellular matrix in the lung must be destroyed for Mycobacterium tuberculosis—the
agent that causes tuberculosis (TB)—to spread. The current paradigm proposes that this …

Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic
antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol …

Background Mycobacterium tuberculosis, the causative agent of tuberculosis, still represents
a major public health threat in many countries. Bioluminescence, the production of light by …

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high
mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix …

Tuberculosis (TB), a chronic infectious disease of global importance, is facing the
emergence of drug-resistant strains with few new drugs to treat the infection. Pulmonary …

Background It is unknown whether lesions in human TB are hypoxic or whether this
influences disease pathology. Human TB is characterised by extensive lung destruction …

Rationale: Tuberculosis kills more than 1.5 million people per year, and standard treatment
has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix …

T cell immunity is essential for the control of tuberculosis (TB), an important disease of the
lung, and is generally studied in humans using peripheral blood cells. Mounting evidence …