RNA interference (RNAi) is a powerful approach for reducing expression of endogenously
expressed proteins. It is widely used for biological applications and is being harnessed to …

Domesticated animals have a large variety of antimicrobial peptides that serve as natural
innate barriers limiting microbial infection or, in some instances, act as an integral …

The airway epithelium is now considered to be central to the orchestration of pulmonary
inflammatory and immune responses, and is also key to tissue remodelling. It acts as the first …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …

Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and …

Studies of patients with severe acute respiratory syndrome (SARS) demonstrate that the
respiratory tract is a major site of SARS-coronavirus (CoV) infection and disease morbidity …

Human β-defensins (HBDs) are antimicrobial peptides that may play a role in mucosal
defense. Diminished activity of these peptides has been implicated in the pathogenesis of …

The severe acute respiratory syndrome (SARS), caused by a novel coronavirus (SARS-
CoV), resulted in substantial morbidity, mortality, and economic losses during the 2003 …

Custom-made zinc-finger nucleases (ZFNs) can induce targeted genome modifications with
high efficiency in cell types including Drosophila, C. elegans, plants, and humans. A …

Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis
(CF), we still lack answers to many questions about the pathogenesis of the disease, and it …