Objectives: Published series on the synchronous combined resection of brain metastases
and primary non-small cell lung cancer are small and scarce. We therefore undertook a …

Background. Lung transplantation (LT) may represent a therapeutic option in case of
advanced pulmonary Langerhans' cell histiocytosis (PLCH). Little is known however about …

Background: Sarcomatoid carcinomas (SCs) are rare tumors that may arise in the lung,
accounting for 0.4% of non–small-cell lung cancers; the prognosis is poor. Only few …

Bone is accrued and maintained primarily through the coupled actions of bone-forming
osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that …

Clinical studies with modulators of the Cystic Fibrosis Transmembrane conductance
Regulator (CFTR) protein have demonstrated that functional restoration of the mutated …

Proline-rich tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase
implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and …

Background: Infection with Burkholderia cepacia complex (BCC) is a life threatening
complication of cystic fibrosis (CF), often seen as a contraindication for lung transplantation …

Since 1975 200 tracheal sleeve resections for iatrogenic tracheal and subglottic laryngeal
stenoses have been performed in our institution. Preoperative Nd: YAG laser is of …

The synthesis, in vitro properties, and in vivo pharmacokinetics for a series of sulfoximine-
substituted trifluoromethylpyrimidines as inhibitors of proline-rich tyrosine kinase, a target for …

Steroid signaling underlies developmental processes in animals. Mutations that impair
steroidogenesis in the fruit fly Drosophila melanogaster provide tools to dissect steroid …