Background: Lung density measurements by computed tomography have previously been
found to be a more sensitive indicator of disease progression in emphysema of α1 …

The aim of the present study was to identify α1-antitrypsin (α1-AT)-deficient patients who had
rapidly progressive disease. PiZ patients (n= 101) underwent annual lung function …

In a 6‐year experiment with a naturally occurring population of viable weed seeds, the
numbers in the top 9 in. of soil decreased exponentially from year to year in the absence of …

Chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death in the UK,
1 causing 26 000 deaths and 240 000 hospital admissions and costing the NHS£ 486 …

Background: Exposure to metal working fluid (MWF) has been associated with outbreaks of
extrinsic allergic alveolitis (EAA) in the USA, with bacterial contamination of MWF being a …

Gamma-glutamyl transferase (GGT) is a clinical marker of biliary disease, but is also of
importance in anti-oxidant metabolic pathways and, consequently, is a potential biomarker …

Seed populations on non-cropped plots (a) left undisturbed,(b) dug twice a year, and (c) dug
four times a year decreased at constant annual rates of 22, 30 and 36%, respectively …

Animal models are invaluable for understanding disease processes and developing
therapeutic strategies. However, there are problems developing the mouse equivalent of the …