User profiles for "author:Novel N Chegou"
Novel N ChegouResearch Scientist (Professor) at Stellenbosch University Verified email at sun.ac.za Cited by 5366 |
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Tuberculosis remains the leading cause of death from an infectious disease worldwide.
Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis …
Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis …
Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis
Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
Tuberculosis assays: past, present and future
Recent developments in the field of TB diagnostics, including the introduction of the Xpert
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …
[HTML][HTML] Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report
Background Interferon gamma release assays, including the QuantiFERON® TB Gold In
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …
[HTML][HTML] Host blood RNA signatures predict the outcome of tuberculosis treatment
EG Thompson, Y Du, ST Malherbe, S Shankar, J Braun… - Tuberculosis, 2017 - Elsevier
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …
Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs …
Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently
needed at points of care in resource-limited settings. We investigated host biomarkers …
needed at points of care in resource-limited settings. We investigated host biomarkers …
Hypercytokinaemia accompanies HIV–tuberculosis immune reconstitution inflammatory syndrome
R Tadokera, G Meintjes… - European …, 2011 - Eur Respiratory Soc
Increased access to combination antiretroviral therapy in areas co-endemic for tuberculosis
(TB) and HIV-1 infection is associated with an increased incidence of immune reconstitution …
(TB) and HIV-1 infection is associated with an increased incidence of immune reconstitution …
[HTML][HTML] RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
A Penn-Nicholson, SK Mbandi, E Thompson… - Scientific reports, 2020 - nature.com
Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic …
needed. We developed a robust and simple, PCR-based host-blood transcriptomic …
[HTML][HTML] Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment …
R Jacobs, S Malherbe, AG Loxton, K Stanley… - Oncotarget, 2016 - ncbi.nlm.nih.gov
There is an urgent need for new tools for the rapid diagnosis of tuberculosis disease. We
evaluated the potentials of 74 host markers as biomarkers for the immunological diagnosis …
evaluated the potentials of 74 host markers as biomarkers for the immunological diagnosis …
[HTML][HTML] Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
Background Inequality is rife throughout South Africa. The first wave of COVID-19 may have
affected people in lower socioeconomic groups worse than the affluent. The SARS-CoV-2 …
affected people in lower socioeconomic groups worse than the affluent. The SARS-CoV-2 …