Effects of the combination of atomoxetine and oxybutynin on OSA endotypic traits
Background We recently showed that administration of the combination of the noradrenergic
drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep greatly reduced …
drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep greatly reduced …
Breath‐holding as a means to estimate the loop gain contribution to obstructive sleep apnoea
L Messineo, L Taranto‐Montemurro… - The Journal of …, 2018 - Wiley Online Library
Key points A hypersensitive ventilatory control system or elevated “loop gain” during sleep is
a primary phenotypic trait causing obstructive sleep apnoea (OSA). Despite the multitude of …
a primary phenotypic trait causing obstructive sleep apnoea (OSA). Despite the multitude of …
Neural ventilatory drive decline as a predominant mechanism of obstructive sleep apnoea events
Background In the classic model of obstructive sleep apnoea (OSA), respiratory events
occur with sleep-related dilator muscle hypotonia, precipitating increased neural ventilatory …
occur with sleep-related dilator muscle hypotonia, precipitating increased neural ventilatory …
Predicting sleep apnea responses to oral appliance therapy using polysomnographic airflow
Abstract Study Objectives Oral appliance therapy is an increasingly common option for
treating obstructive sleep apnea (OSA) in patients who are intolerant to continuous positive …
treating obstructive sleep apnea (OSA) in patients who are intolerant to continuous positive …
Atomoxetine and fesoterodine combination improves obstructive sleep apnoea severity in patients with milder upper airway collapsibility
L Messineo, L Taranto‐Montemurro, N Calianese… - …, 2022 - Wiley Online Library
Background and objective The combination of the noradrenergic atomoxetine plus the anti‐
muscarinic oxybutynin acutely increased genioglossus activity and reduced obstructive …
muscarinic oxybutynin acutely increased genioglossus activity and reduced obstructive …
Ventilatory drive withdrawal rather than reduced genioglossus compensation as a mechanism of obstructive sleep apnea in REM sleep
L Messineo, DJ Eckert… - American journal of …, 2022 - atsjournals.org
Rationale: REM sleep is associated with reduced ventilation and greater obstructive sleep
apnea (OSA) severity than non-REM (nREM) sleep for reasons that have not been fully …
apnea (OSA) severity than non-REM (nREM) sleep for reasons that have not been fully …
Clinical polysomnographic methods for estimating pharyngeal collapsibility in obstructive sleep apnea
Abstract Study Objectives Obstructive sleep apnea has major health consequences but is
challenging to treat. For many therapies, efficacy is determined by the severity of underlying …
challenging to treat. For many therapies, efficacy is determined by the severity of underlying …
Effect of pimavanserin on the respiratory arousal threshold from sleep: a randomized trial
L Messineo, L Gell, N Calianese, T Sofer… - Annals of the …, 2022 - atsjournals.org
Rationale: A low respiratory arousal threshold is a key endotype responsible for obstructive
sleep apnea (OSA) pathogenesis. Pimavanserin is an antiserotoninergic capable of …
sleep apnea (OSA) pathogenesis. Pimavanserin is an antiserotoninergic capable of …
Impact of cold and flu medication on obstructive sleep apnoea and its underlying traits: a pilot randomized controlled trial
Background and objective Animal studies indicate that alpha‐1 adrenergic receptor agonists
and antimuscarinic agents improve genioglossus muscle activity during sleep and may be …
and antimuscarinic agents improve genioglossus muscle activity during sleep and may be …
Treatment of Sleep Apnea and Reduction in Blood Pressure: The Role of Heart Rate Response and Hypoxic Burden
BACKGROUND: Obstructive sleep apnea is associated with increased blood pressure (BP).
Obstructive sleep apnea treatment reduces BP with substantial variability, not explained by …
Obstructive sleep apnea treatment reduces BP with substantial variability, not explained by …