Effects of the combination of atomoxetine and oxybutynin on OSA endotypic traits

L Taranto-Montemurro, L Messineo, A Azarbarzin… - Chest, 2020 - Elsevier
Background We recently showed that administration of the combination of the noradrenergic
drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep greatly reduced …

Breath‐holding as a means to estimate the loop gain contribution to obstructive sleep apnoea

L Messineo, L Taranto‐Montemurro… - The Journal of …, 2018 - Wiley Online Library
Key points A hypersensitive ventilatory control system or elevated “loop gain” during sleep is
a primary phenotypic trait causing obstructive sleep apnoea (OSA). Despite the multitude of …

Neural ventilatory drive decline as a predominant mechanism of obstructive sleep apnoea events

LK Gell, D Vena, RM Alex, A Azarbarzin, N Calianese… - Thorax, 2022 - thorax.bmj.com
Background In the classic model of obstructive sleep apnoea (OSA), respiratory events
occur with sleep-related dilator muscle hypotonia, precipitating increased neural ventilatory …

Predicting sleep apnea responses to oral appliance therapy using polysomnographic airflow

D Vena, A Azarbarzin, M Marques, S Op de Beeck… - Sleep, 2020 - academic.oup.com
Abstract Study Objectives Oral appliance therapy is an increasingly common option for
treating obstructive sleep apnea (OSA) in patients who are intolerant to continuous positive …

Atomoxetine and fesoterodine combination improves obstructive sleep apnoea severity in patients with milder upper airway collapsibility

L Messineo, L Taranto‐Montemurro, N Calianese… - …, 2022 - Wiley Online Library
Background and objective The combination of the noradrenergic atomoxetine plus the anti‐
muscarinic oxybutynin acutely increased genioglossus activity and reduced obstructive …

Ventilatory drive withdrawal rather than reduced genioglossus compensation as a mechanism of obstructive sleep apnea in REM sleep

L Messineo, DJ Eckert… - American journal of …, 2022 - atsjournals.org
Rationale: REM sleep is associated with reduced ventilation and greater obstructive sleep
apnea (OSA) severity than non-REM (nREM) sleep for reasons that have not been fully …

Clinical polysomnographic methods for estimating pharyngeal collapsibility in obstructive sleep apnea

D Vena, L Taranto-Montemurro, A Azarbarzin… - Sleep, 2022 - academic.oup.com
Abstract Study Objectives Obstructive sleep apnea has major health consequences but is
challenging to treat. For many therapies, efficacy is determined by the severity of underlying …

Effect of pimavanserin on the respiratory arousal threshold from sleep: a randomized trial

L Messineo, L Gell, N Calianese, T Sofer… - Annals of the …, 2022 - atsjournals.org
Rationale: A low respiratory arousal threshold is a key endotype responsible for obstructive
sleep apnea (OSA) pathogenesis. Pimavanserin is an antiserotoninergic capable of …

Impact of cold and flu medication on obstructive sleep apnoea and its underlying traits: a pilot randomized controlled trial

L Taranto‐Montemurro, S Sands, A Azarbarzin… - …, 2021 - Wiley Online Library
Background and objective Animal studies indicate that alpha‐1 adrenergic receptor agonists
and antimuscarinic agents improve genioglossus muscle activity during sleep and may be …

Treatment of Sleep Apnea and Reduction in Blood Pressure: The Role of Heart Rate Response and Hypoxic Burden

L Messineo, S Sands, C Schmickl, G Labarca… - …, 2024 - Am Heart Assoc
BACKGROUND: Obstructive sleep apnea is associated with increased blood pressure (BP).
Obstructive sleep apnea treatment reduces BP with substantial variability, not explained by …