Background Most patients with an exacerbation of chronic obstructive pulmonary disease
(COPD) are treated with antibiotics. However the value of their use remains uncertain. Some …

Recommendations in asthma guidelines presuppose that practitioners have the evidence,
information, knowledge, and tools to select inhaler devices appropriate for individual …

Inhaler device errors are common and may impact the effectiveness of the delivered drug.
There is a paucity of up-to-date systematic reviews (SRs) or meta-analyses (MAs) of device …

The concept of reducing cancer risk by chemoprevention has become an important aspect of
current cancer research (Boone et al., 1990). The anti-estrogen, tamoxifen, introduced to …

In order to determine whether the airway inflammatory cells of chronic obstructive pulmonary
disease (COPD) are different from those seen in asthma, we have studied a subepithelial …

Rationale: Accumulation of eosinophils in the bronchial mucosa of individuals with asthma is
considered to be a central event in the pathogenesis of asthma. In animal models, airway …

Background The short-term benefits of inhaled corticosteroids for patients with chronic
obstructive pulmonary disease (COPD) are greater in patients with evidence of eosinophilic …

Eosinophil-derived TGF-β has been implicated in remodeling events in asthma. We
hypothesized that reduction of bronchial mucosal eosinophils with anti–IL-5 would reduce …

We investigated the efficacy and safety of dual bronchodilation with QVA149 versus its
monocomponents indacaterol and glycopyrronium, tiotropium and placebo in patients with …

Rationale: No currently available treatment is reported to reduce the exaggerated airway
wall inflammation of chronic obstructive pulmonary disease. Objectives: We tested the …