Innate immune recognition in infectious and noninfectious diseases of the lung

B Opitz, V van Laak, J Eitel, N Suttorp - American journal of …, 2010 - atsjournals.org
Diseases of the respiratory tract are among the leading causes of death in the world
population. Increasing evidence points to a key role of the innate immune system with its …

Recognition of Streptococcus pneumoniae by the innate immune system

U Koppe, N Suttorp, B Opitz - Cellular microbiology, 2012 - Wiley Online Library
Streptococcus pneumoniae is both a frequent colonizer of the upper respiratory tract and a
leading cause of life‐threatening infections such as pneumonia, meningitis and sepsis. The …

[HTML][HTML] Lung epithelium as a sentinel and effector system in pneumonia–molecular mechanisms of pathogen recognition and signal transduction

S Hippenstiel, B Opitz, B Schmeck, N Suttorp - Respiratory research, 2006 - Springer
Pneumonia, a common disease caused by a great diversity of infectious agents is
responsible for enormous morbidity and mortality worldwide. The bronchial and lung …

[HTML][HTML] COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

…, S Schmidt, F Balzer, J Liebig, J Loske, N Suttorp… - Nature …, 2020 - nature.com
To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …

[PDF][PDF] Severe COVID-19 is marked by a dysregulated myeloid cell compartment

…, R Geffers, M Witzenrath, C Drosten, N Suttorp… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

[HTML][HTML] SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

…, MA Müller, A Hocke, M Witzenrath, N Suttorp… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly
unfolding coronavirus disease 2019 (COVID-19) pandemic 1, 2. Clinical manifestations of …

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

…, NW Gale, M Witzenrath, S Rosseau, N Suttorp… - Nature medicine, 2006 - nature.com
Abstract The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor
tyrosine kinase Tie-2 (refs.,). Paracrine Ang-1–mediated activation of Tie-2 acts as a …

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort …

…, H Gruell, P Kopankiewicz, N Suttorp… - The Lancet …, 2021 - thelancet.com
Background Heterologous vaccine regimens have been widely discussed as a way to
mitigate intermittent supply shortages and to improve immunogenicity and safety of COVID …

[PDF][PDF] A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model

…, AC Hocke, S Hippenstiel, M Witzenrath, N Suttorp… - Cell, 2020 - cell.com
The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019
(COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed …

[PDF][PDF] Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection

…, WM Kuebler, M Mülleder, C Drosten, N Suttorp… - Cell systems, 2020 - cell.com
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …