Apoptosis and epithelial injury in the lungs
TR Martin, N Hagimoto, M Nakamura… - Proceedings of the …, 2005 - atsjournals.org
Epithelial injury is a critical event in the development of acute lung injury, but the
mechanisms that cause death of the alveolar epithelium are not completely understood …
mechanisms that cause death of the alveolar epithelium are not completely understood …
P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis.
…, M Kawasaki, Y Nomoto, N Hagimoto… - American journal of …, 1996 - atsjournals.org
The tumor suppressor p53 protein is a transcription factor that plays a central role in the
cellular response to DNA damage, and it can cause either G1 arrest or apoptosis. Recently …
cellular response to DNA damage, and it can cause either G1 arrest or apoptosis. Recently …
[HTML][HTML] Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
K Kuwano, N Hagimoto, M Kawasaki… - The Journal of …, 1999 - Am Soc Clin Investig
The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the
major effector molecules of cytotoxic T lymphocytes and natural killer cells. Previously, we …
major effector molecules of cytotoxic T lymphocytes and natural killer cells. Previously, we …
Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen
N Hagimoto, K Kuwano, H Miyazaki… - American journal of …, 1997 - atsjournals.org
Fas antigen is a cell surface protein that mediates apoptosis, and it is expressed in various
cells and tissues. Fas ligand binds to its receptor Fas, thus inducing apoptosis of Fas …
cells and tissues. Fas ligand binds to its receptor Fas, thus inducing apoptosis of Fas …
Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice.
N Hagimoto, K Kuwano, Y Nomoto… - American journal of …, 1997 - atsjournals.org
The incidence of apoptosis and the expression of Fas antigen (Fas)/Fas ligand (FasL)
mRNA in bleomycin-induced pulmonary fibrosis in mice were examined. Male ICR mice …
mRNA in bleomycin-induced pulmonary fibrosis in mice were examined. Male ICR mice …
TGF-β1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
N Hagimoto, K Kuwano, I Inoshima… - The Journal of …, 2002 - journals.aai.org
Transforming growth factor-β1 (TGF-β1) has important roles in lung fibrosis and the potential
to induce apoptosis in several types of cells. We previously demonstrated that apoptosis of …
to induce apoptosis in several types of cells. We previously demonstrated that apoptosis of …
Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor
M Kawasaki, K Kuwano, N Hagimoto, T Matsuba… - The American journal of …, 2000 - Elsevier
LPS (lipopolysaccharide) is one of the major factors that induce acute lung injury. Recently,
it was reported that LPS induced disseminated endothelial apoptosis, preceding …
it was reported that LPS induced disseminated endothelial apoptosis, preceding …
Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice
…, K Kuwano, M Yamada, N Hagimoto… - The Journal of …, 2005 - journals.aai.org
Vascular endothelial growth factor (VEGF) is an angiogenesis factor with proinflammatory
roles. Flt-1 is one of the specific receptors for VEGF, and soluble flt-1 (sflt-1) binds to VEGF …
roles. Flt-1 is one of the specific receptors for VEGF, and soluble flt-1 (sflt-1) binds to VEGF …
Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias
…, N Nakashima, I Inoshima, N Hagimoto… - European …, 2003 - Eur Respiratory Soc
Lung epithelial cells are a primary target for reactive oxygen species (ROS). ROS can cause
oxidative deoxyribonucleic acid modification, such as 8-hydroxy-deoxyguanosine (8-OHdG) …
oxidative deoxyribonucleic acid modification, such as 8-hydroxy-deoxyguanosine (8-OHdG) …
Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor
…, R Kunitake, T Maeyama, N Hagimoto… - … of Physiology-Lung …, 2001 - journals.physiology.org
Caspases have been implicated in the effector process of apoptosis in several systems
including the Fas-Fas ligand pathway. We previously demonstrated that excessive apoptosis …
including the Fas-Fas ligand pathway. We previously demonstrated that excessive apoptosis …