BACKGROUND: Both gastrointestinal microbiota composition and cesarean section have
been linked to atopic manifestations. However, results are inconsistent, and the …

Atopy is generally considered to be caused by interaction of genetic and environmental
factors. Recently, an association of a C-to-T transition in the promoter region of the CD14 …

Background Epidemiological studies have reported adverse effects of ambient air pollution
on the prevalence of asthma. Laboratory studies have suggested that innate immune …

REFERENCES 1. Schmidt-Weber CB, Akdis M, Akdis CA. Th17 cells in the big picture of
immunology. J Allergy Clin Immunol 2007; 120: 247-54. 2. Hellings PW, Kasran A, Liu Z …

To cite this article: Reijmerink NE, Bottema RWB, Kerkhof M, Gerritsen J, Stelma FF, Thijs C,
van Schayck CP, Smit HA, Brunekreef B, Koppelman GH, Postma DS. TLR‐related pathway …

BACKGROUND: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2
inflammatory responses and eosinophilia. Single nucleotide polymorphisms (SNPs) in …

Studying gene–environment interactions may elucidate the complex origins of atopic
diseases but requires large study populations. Pooling data from several cohort studies may …

BACKGROUND: Regulatory T–cell dysfunction is associated with development of the
complex genetic conditions atopy and asthma. Therefore, we hypothesized that single …

Introduction: ADAM33 is the first identified asthma gene by positional cloning, especially
asthma combined with bronchial hyperresponsiveness (BHR). Moreover, ADAM33 is …

To cite this article: Bottema RWB, Kerkhof M, Reijmerink NE, Koppelman GH, Thijs C, Stelma
FF, Smit HA, Brunekreef B, van Schayck CP, Postma DS. X‐chromosome Forkhead Box P3 …