Airway epithelial changes in smokers but not in ex-smokers with asthma

M Broekema, NHT ten Hacken, F Volbeda… - American journal of …, 2009 - atsjournals.org
Rationale: Smoking has detrimental effects on asthma outcome, such as increased cough,
wheezing, sputum production, and frequency of asthma attacks. This results in accelerated …

Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma

M Broekema, W Timens, JM Vonk… - American journal of …, 2011 - atsjournals.org
Rationale: Individuals with asthma may outgrow symptoms despite not using treatment,
whereas others reach complete remission (CoR) with absence of airway obstruction and …

[HTML][HTML] Expression of ADAMs (“a disintegrin and metalloprotease”) in the human lung

A Dijkstra, DS Postma, JA Noordhoek, ME Lodewijk… - Virchows Archiv, 2009 - Springer
In view of the associations of “a disintegrin and metalloprotease”(ADAM) with respiratory
diseases, we assessed the expression of various ADAMs in human lung tissue. Lung tissue …

[HTML][HTML] Advanced glycation endproducts and their receptor in different body compartments in COPD

SJM Hoonhorst, AT Lo Tam Loi, SD Pouwels, A Faiz… - Respiratory …, 2016 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a chronic lung disease
characterized by chronic airway inflammation and emphysema, and is caused by exposure …

Clinical control of asthma associates with measures of airway inflammation

F Volbeda, M Broekema, ME Lodewijk, MN Hylkema… - Thorax, 2013 - thorax.bmj.com
Background Control of asthma is the goal of asthma management worldwide. The Global
Initiative for Asthma defined control by a composite measure of clinical findings and future …

Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema

DMLW Kruk, M Wisman, HG Bruin… - … of Physiology-Lung …, 2021 - journals.physiology.org
Mesenchymal stromal cells (MSCs) may provide crucial support in the regeneration of
destructed alveolar tissue (emphysema) in chronic obstructive pulmonary disease (COPD) …

[HTML][HTML] Susceptibility to COPD: differential proteomic profiling after acute smoking

L Franciosi, DS Postma, M Van den Berge… - PLoS …, 2014 - journals.plos.org
Cigarette smoking is the main risk factor for COPD (Chronic Obstructive Pulmonary
Disease), yet only a subset of smokers develops COPD. Family members of patients with …

Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides

MA Breukels, A Zandvoort… - Infection and …, 2001 - Am Soc Microbiol
Protection against infections with Streptococcus pneumoniae depends on the presence of
antibodies against capsular polysaccharides that facilitate phagocytosis. Asplenic patients …

Proteomic analysis of human epithelial lining fluid by microfluidics‐based nano LC‐MS/MS: A feasibility study

L Franciosi, N Govorukhina, F Fusetti… - …, 2013 - Wiley Online Library
Microfluidics‐based nano LC‐MS/MS (chip LC‐MS/MS) was used to identify and quantify
proteins in epithelial lining fluid (ELF), collected during bronchoscopy from the main bronchi …

[HTML][HTML] [18F]FDG Uptake in Adipose Tissue Is Not Related to Inflammation in Type 2 Diabetes Mellitus

M Reijrink, SA de Boer, IF Antunes, DS Spoor… - Molecular Imaging and …, 2021 - Springer
Abstract Purpose 2-deoxy-2-[18 F] fluoro-d-glucose ([18 F] FDG) uptake is a marker of
metabolic activity and is therefore used to measure the inflammatory state of several tissues …