Influenza virus infectivity is retained in aerosols and droplets independent of relative humidity
KA Kormuth, K Lin, AJ Prussin… - The Journal of …, 2018 - academic.oup.com
Pandemic and seasonal influenza viruses can be transmitted through aerosols and droplets,
in which viruses must remain stable and infectious across a wide range of environmental …
in which viruses must remain stable and infectious across a wide range of environmental …
[HTML][HTML] A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry
Abstract SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for the global
pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to host lung …
pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to host lung …
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells
MM Myerburg, JD King Jr, NM Oyster… - American journal of …, 2010 - atsjournals.org
The metabolic sensor AMP-activated kinase (AMPK) inhibits both the cystic fibrosis (CF)
transmembrane conductance regulator (CFTR) Cl− channel and epithelial Na+ channel …
transmembrane conductance regulator (CFTR) Cl− channel and epithelial Na+ channel …
Acute regulation of the epithelial sodium channel in airway epithelia by proteases and trafficking
MM Myerburg, PR Harvey, EM Heidrich… - American journal of …, 2010 - atsjournals.org
Effective clearance of inhaled pathogens is the primary innate defense mechanism in the
lung, and requires the maintenance of a proper airway surface liquid (ASL) volume to …
lung, and requires the maintenance of a proper airway surface liquid (ASL) volume to …
[HTML][HTML] Effect of ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis patients with G551D-CFTR
SH Donaldson, BL Laube, TE Corcoran… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. The ability to restore cystic fibrosis transmembrane regulator (CFTR)
function with effective small molecule modulators in patients with cystic fibrosis provides an …
function with effective small molecule modulators in patients with cystic fibrosis provides an …
[HTML][HTML] Tgf-β1 inhibits Cftr biogenesis and prevents functional rescue of ΔF508-Cftr in primary differentiated human bronchial epithelial cells
SM Snodgrass, KM Cihil, PK Cornuet, MM Myerburg… - PloS one, 2013 - journals.plos.org
CFTR is an integral transmembrane glycoprotein and a cAMP-activated Cl− channel.
Mutations in the CFTR gene lead to Cystic Fibrosis (CF)–an autosomal recessive disease …
Mutations in the CFTR gene lead to Cystic Fibrosis (CF)–an autosomal recessive disease …
[HTML][HTML] Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa
MB Butterworth, L Zhang, EM Heidrich… - Journal of Biological …, 2012 - ASBMB
Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to the
mortality of patients with cystic fibrosis. Chronic infection by Pseudomonas induces …
mortality of patients with cystic fibrosis. Chronic infection by Pseudomonas induces …
Human Lung-Resident Macrophages Colocalize with and Provide Costimulation to PD1hi Tissue-Resident Memory T Cells
Rationale: Tissue-resident memory T cells (TRM) play a critical role in the defense against
inhaled pathogens. The isolation and study of human lung tissue–resident memory T cells …
inhaled pathogens. The isolation and study of human lung tissue–resident memory T cells …
Environmental persistence of influenza viruses is dependent upon virus type and host origin
Highly transmissible influenza viruses (IV) must remain stable and infectious under a wide
range of environmental conditions following release from the respiratory tract into the air …
range of environmental conditions following release from the respiratory tract into the air …
The receptor for advanced glycation end products is a critical mediator of type 2 cytokine signaling in the lungs
TN Perkins, EA Oczypok, RE Dutz, ML Donnell… - Journal of Allergy and …, 2019 - Elsevier
Background Asthma is estimated to effect more than 300 million persons worldwide, leading
to nearly 250,000 deaths annually. The majority of patients with mild-to-severe asthma have …
to nearly 250,000 deaths annually. The majority of patients with mild-to-severe asthma have …