Chronic pain has been recognized as pain that persists past normal healing time 5 and
hence lacks the acute warning function of physiological nociception. 35 Usually pain is …

Chronic pain is a major source of suffering. It interferes with daily functioning and often is
accompanied by distress. Yet, in the International Classification of Diseases, chronic pain …

The number of angiosperm species for which nuclear DNA amount estimates have been
made has nearly trebled since the last collected lists of such values were published, and …

Background Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease
that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown …

This is a revision of guidelines, originally published in 2004, for the assessment of patients
with neuropathic pain. Neuropathic pain is defined as pain arising as a direct consequence …

Recent evidence has defined an important role for PPARα in the transcriptional control of
cardiac energy metabolism. To investigate the role of PPARα in the genesis of the metabolic …

Here we provide the updated version of the guidelines of the European Association for
Palliative Care (EAPC) on the use of opioids for the treatment of cancer pain. The update …

Progress in the understanding of chronic pain with neuropathic features has been hindered
by a lack of epidemiologic research in the general population. The Leeds Assessment of …

This study describes the development and validation of a novel tool for identifying patients in
whom neuropathic mechanisms dominate their pain experience. The Leeds assessment of …

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …