The pulmonary endothelium is a dynamic, metabolically active layer of squamous
endothelial cells ideally placed to mediate key processes involved in lung homoeostasis …

Acute lung injury (ALI) and acute respiratory distress syndrome are characterized by protein
rich alveolar edema, reduced lung compliance, and acute severe hypoxemia. A degree of …

Context Extracorporeal membrane oxygenation (ECMO) can support gas exchange in
patients with severe acute respiratory distress syndrome (ARDS), but its role has remained …

Rationale: Loss of skeletal muscle mass and function is a common consequence of critical
illness and a range of chronic diseases, but the mechanisms by which this occurs are …

Cardiac surgery using cardiopulmonary by-pass and, to a greater extent, lung resection,
causes acute lung injury that is usually subclinical. Analysis of mediators in exhaled breath …

Background Surgery can lead to significant muscle loss, which increases recovery time and
associates with increased mortality. Muscle loss is not uniform, with some patients losing …

Objective: To test whether simvastatin improves physiological and biological outcomes in
patients undergoing esophagectomy. Background: One-lung ventilation during …

The orofacial manifestations of 44 HIV‐infected individuals from the South West of England
are reported. Oral candidiasis, periodontal disease and cervical lymphadenopathy were the …

Background and objective N‐acetylcysteine has been used to treat a variety of lung
diseases, where is it thought to have an antioxidant effect. In a randomized placebo …

Background Molecular pathways that regulate alveolar development and adult repair
represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA) …