NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced
cost of£ 100 for each volume (normally comprising 30–40 titles). The commercial …

The importance of health research utilisation in policy-making, and of understanding the
mechanisms involved, is increasingly recognised. Recent reports calling for more resources …

Given the increased use of economic evaluation to inform decision making in the health
service, it is particularly important that the research methods used are critically assessed …

Post-acute covid-19 (“long covid”) seems to be a multisystem disease, sometimes occurring
after a relatively mild acute illness. 1 Clinical management requires a whole-patient …

Importance Evidence regarding corticosteroid use for severe coronavirus disease 2019
(COVID-19) is limited. Objective To determine whether hydrocortisone improves outcome for …

Importance Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …

The role of modelling in economic evaluation is explored by discussing, with examples, the
uses of models. The expanded use of pragmatic clinical trials as an alternative to models is …

Background The genetic and clinical heterogeneity of breast cancer makes the identification
of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively …

Background Previous studies have independently validated the prognostic relevance of
residual cancer burden (RCB) after neoadjuvant chemotherapy. We used results from …

Context Prediction of high probability of survival from standard cancer treatments is
fundamental for individualized cancer treatment strategies. Objective To develop a predictor …