On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B. 1.1.
529 was announced, containing far more mutations in Spike (S) than previously reported …

Objective To develop and validate a pragmatic risk score to predict mortality in patients
admitted to hospital with coronavirus disease 2019 (covid-19). Design Prospective …

Background Microbiological characterisation of co-infections and secondary infections in
patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe …

Background Prognostic models to predict the risk of clinical deterioration in acute COVID-19
cases are urgently required to inform clinical management decisions. Methods We …

Background COVID-19 is a multisystem disease and patients who survive might have in-
hospital complications. These complications are likely to have important short-term and long …

Background Studies of patients admitted to hospital with COVID-19 have found varying
mortality outcomes associated with underlying respiratory conditions and inhaled …

Background Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving
limited insights into mucosal defences that prevent viral replication and onward …

Background Early in the pandemic it was suggested that pre-existing use of non-steroidal
anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with …

Background Mortality rates in hospitalised patients with COVID-19 in the UK appeared to
decline during the first wave of the pandemic. We aimed to quantify potential drivers of this …

Serological detection of antibodies to SARS-CoV-2 is essential for establishing rates of
seroconversion in populations, and for seeking evidence for a level of antibody that may be …