The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that'walls off'the infecting …

▪ Abstract Pathogenic mycobacteria, including the causative agents of tuberculosis and
leprosy, are responsible for considerable morbidity and mortality worldwide. A hallmark of …

Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid
apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional …

Granulomas, organized aggregates of immune cells, form in response to persistent stimuli
and are hallmarks of tuberculosis. Tuberculous granulomas have long been considered host …

Treatment of tuberculosis, a complex granulomatous disease, requires long-term multidrug
therapy to overcome tolerance, an epigenetic drug resistance that is widely attributed to …

Infection of vertebrate hosts with pathogenic Mycobacteria, the agents of tuberculosis,
produces granulomas, highly organized structures containing differentiated macrophages …

Cloud computing has seen tremendous growth, particularly for commercial web
applications. The on-demand, pay-as-you-go model creates a flexible and cost-effective …

The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis,
depends on its ability to invade the host, replicate, and transmit infection. At its initial …

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of …