Endothelial injury is often identified as a hallmark of ARDS. 1–6 Yet endothelial cells may be
altered in other ways besides frank injury in ARDS and in other pathologic syndromes. A …

Platelets are specialized hemostatic cells that circulate in the blood as anucleate cytoplasts.
We report that platelets unexpectedly possess a functional spliceosome, a complex that …

Development of the pulmonary system is essential for terrestrial life. The molecular
pathways that regulate this complex process are beginning to be defined, and such …

Research within the anatomical sciences often relies on human cadaveric tissues. Without
the good will of these donors who allow us to use their bodies to push forward our …

This paper is focused on unique insights provided by the preterm lamb physiological model
of bronchopulmonary dysplasia (BPD). Connections are also made to insights provided by …

The cardioprotective effects of an mAb to P-selectin designated mAb PB1. 3 was examined
in a feline model of myocardial ischemia (MI) and reperfusion. PB1. 3 (1 mg/kg) …

Neutrophils are highly specialized innate effector cells that have evolved for killing of
pathogens. Human neonates have a common multifactorial syndrome of neutrophil …

After budding, the human immunodeficiency virus (HIV) must 'mature'into an infectious viral
particle. Viral maturation requires proteolytic processing of the Gag polyprotein at the matrix …

In a multicenter registry conducted over 2 yr of patients with acute respiratory distress
syndrome (ARDS), we enrolled 153 patients and collected data dally for 7 consecutive days …

Apoptosis mediated by Fas/Fas ligand (FasL) interaction has been implicated in human
disease processes, including pulmonary disorders. However, the role of the Fas/FasL …