User profiles for "author:Kenneth A Mclean"

Kenneth McLean

University of Edinburgh
Verified email at ed.ac.uk
Cited by 6578

[PDF][PDF] SARS-CoV-2 Omicron-B. 1.1. 529 leads to widespread escape from neutralizing antibody responses

W Dejnirattisai, J Huo, D Zhou, J Zahradník, P Supasa… - Cell, 2022 - cell.com
On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B. 1.1.
529 was announced, containing far more mutations in Spike (S) than previously reported …

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C …

SR Knight, A Ho, R Pius, I Buchan, G Carson… - bmj, 2020 - bmj.com
Objective To develop and validate a pragmatic risk score to predict mortality in patients
admitted to hospital with coronavirus disease 2019 (covid-19). Design Prospective …

[HTML][HTML] Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study

J Glasbey, A Ademuyiwa, A Adisa, E AlAmeer… - The Lancet …, 2021 - thelancet.com
Background Surgery is the main modality of cure for solid cancers and was prioritised to
continue during COVID-19 outbreaks. This study aimed to identify immediate areas for …

[HTML][HTML] Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP …

CD Russell, CJ Fairfield, TM Drake, L Turtle… - The Lancet …, 2021 - thelancet.com
Background Microbiological characterisation of co-infections and secondary infections in
patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe …

Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study

COVIDSurg Collaborative… - …, 2021 - Wiley Online Library
Summary Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim
of this study was to determine the optimal duration of planned delay before surgery in …

[HTML][HTML] Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective …

TM Drake, AM Riad, CJ Fairfield, C Egan, SR Knight… - The Lancet, 2021 - thelancet.com
Background COVID-19 is a multisystem disease and patients who survive might have in-
hospital complications. These complications are likely to have important short-term and long …

[HTML][HTML] Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

RK Gupta, EM Harrison, A Ho, AB Docherty… - The Lancet …, 2021 - thelancet.com
Background Prognostic models to predict the risk of clinical deterioration in acute COVID-19
cases are urgently required to inform clinical management decisions. Methods We …

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using …

CI Bloom, TM Drake, AB Docherty… - The Lancet …, 2021 - thelancet.com
Background Studies of patients admitted to hospital with COVID-19 have found varying
mortality outcomes associated with underlying respiratory conditions and inhaled …

[HTML][HTML] SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

F Liew, S Talwar, A Cross, BJ Willett, S Scott… - …, 2023 - thelancet.com
Background Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving
limited insights into mucosal defences that prevent viral replication and onward …

[HTML][HTML] Global burden of acute lower respiratory infection associated with human parainfluenza virus in children younger than 5 years for 2018: a systematic review …

X Wang, Y Li, M Deloria-Knoll, SA Madhi… - The Lancet Global …, 2021 - thelancet.com
Background Human parainfluenza virus (hPIV) is a common virus in childhood acute lower
respiratory infections (ALRI). However, no estimates have been made to quantify the global …