[HTML][HTML] Fetal nutrition and adult disease
KM Godfrey, DJP Barker - The American journal of clinical nutrition, 2000 - Elsevier
Recent research suggests that several of the major diseases of later life, including coronary
heart disease, hypertension, and type 2 diabetes, originate in impaired intrauterine growth …
heart disease, hypertension, and type 2 diabetes, originate in impaired intrauterine growth …
Origins of lifetime health around the time of conception: causes and consequences
Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …
affect the health and chronic disease risk of people throughout their lives, as captured in the …
Fetal programming and adult health
KM Godfrey, DJP Barker - Public health nutrition, 2001 - cambridge.org
Low birthweight is now known to be associated with increased rates of coronary heart
disease and the related disorders stroke, hypertension and non-insulin dependent diabetes …
disease and the related disorders stroke, hypertension and non-insulin dependent diabetes …
Maternal vitamin D status during pregnancy and child outcomes
Objective: To investigate whether exposure to high maternal concentrations of 25 (OH)-
vitamin D in pregnancy poses any risk to the child. Design: Prospective study. Setting …
vitamin D in pregnancy poses any risk to the child. Design: Prospective study. Setting …
Epigenetic gene promoter methylation at birth is associated with child's later adiposity
KM Godfrey, A Sheppard, PD Gluckman… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity.
In animal models, maternal diet alters offspring body composition, accompanied by …
In animal models, maternal diet alters offspring body composition, accompanied by …
Influence of maternal obesity on the long-term health of offspring
KM Godfrey, RM Reynolds, SL Prescott… - The lancet Diabetes & …, 2017 - thelancet.com
In addition to immediate implications for pregnancy complications, increasing evidence
implicates maternal obesity as a major determinant of offspring health during childhood and …
implicates maternal obesity as a major determinant of offspring health during childhood and …
[HTML][HTML] Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial
Background Behavioural interventions might improve clinical outcomes in pregnant women
who are obese. We aimed to investigate whether a complex intervention addressing diet …
who are obese. We aimed to investigate whether a complex intervention addressing diet …
[HTML][HTML] Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
KM Godfrey, KA Lillycrop, GC Burdge, PD Gluckman… - Pediatric …, 2007 - nature.com
There is now considerable evidence that elements of the heritable or familial component of
disease susceptibility are transmitted by nongenomic means, and that environmental …
disease susceptibility are transmitted by nongenomic means, and that environmental …
Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that …
KA Lillycrop, JL Slater-Jefferies, MA Hanson… - British Journal of …, 2007 - cambridge.org
Prenatal nutritional constraint induces an altered metabolic phenotype in the offspring which
in humans confers an increased risk of non-communicable disease. Feeding a protein …
in humans confers an increased risk of non-communicable disease. Feeding a protein …
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
JS Ried, J Li, XB Zuo, XD Zheng, XY Yin, LD Sun… - Nature …, 2015 - nature.com
Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for …
predominantly in populations of European ancestry. To identify further susceptibility loci for …