Methodological challenges in utilizing mi RNA s as circulating biomarkers
L Moldovan, KE Batte, J Trgovcich… - Journal of cellular …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …
control of gene expression. The discovery of their presence not only in tissues but also in …
Macrophage microvesicles induce macrophage differentiation and miR-223 transfer
N Ismail, Y Wang, D Dakhlallah… - Blood, The Journal …, 2013 - ashpublications.org
Microvesicles are small membrane-bound particles comprised of exosomes and various-
sized extracellular vesicles. These are released by several cell types. Microvesicles have a …
sized extracellular vesicles. These are released by several cell types. Microvesicles have a …
Gene expression networks in COPD: microRNA and mRNA regulation
Background The mechanisms underlying chronic obstructive pulmonary disease (COPD)
remain unclear. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that …
remain unclear. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that …
Epigenetic Regulation of miR-17∼92 Contributes to the Pathogenesis of Pulmonary Fibrosis
D Dakhlallah, K Batte, Y Wang… - American journal of …, 2013 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung fibrosis with a
high mortality rate. In organ repair and remodeling, epigenetic events are important …
high mortality rate. In organ repair and remodeling, epigenetic events are important …
MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer
M Crawford, K Batte, L Yu, X Wu, GJ Nuovo… - Biochemical and …, 2009 - Elsevier
Lung cancer is the most frequent cause of cancer-related death in this country for men and
women. MicroRNAs (miRNAs) are a family of small non-coding RNAs (approximately 21 …
women. MicroRNAs (miRNAs) are a family of small non-coding RNAs (approximately 21 …
Exosome-derived miR-25-3p and miR-92a-3p stimulate liposarcoma progression
Despite the development of combined modality treatments against liposarcoma in recent
years, a significant proportion of patients respond only modestly to such approaches …
years, a significant proportion of patients respond only modestly to such approaches …
[HTML][HTML] Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes
Background The molecular pathways involved in the interstitial lung diseases (ILDs) are
poorly understood. Systems biology approaches, with global expression data sets, were …
poorly understood. Systems biology approaches, with global expression data sets, were …
Analyzing the circulating microRNAs in exosomes/extracellular vesicles from serum or plasma by qRT-PCR
L Moldovan, K Batte, Y Wang, J Wisler… - … MicroRNAs: Methods and …, 2013 - Springer
Small extracellular vesicles are released from both healthy and disease cells to facilitate
cellular communication. They have a wide variety of names including exosomes …
cellular communication. They have a wide variety of names including exosomes …
[HTML][HTML] HDAC8, a potential therapeutic target for the treatment of malignant peripheral nerve sheath tumors (MPNST)
G Lopez, KLJ Bill, HK Bid, D Braggio, D Constantino… - PLoS …, 2015 - journals.plos.org
Introduction HDAC isoform-specific inhibitors may improve the therapeutic window while
limiting toxicities. Developing inhibitors against class I isoforms poses difficulties as they …
limiting toxicities. Developing inhibitors against class I isoforms poses difficulties as they …
[HTML][HTML] β-catenin S45F mutation results in apoptotic resistance
Wnt/β-catenin signaling is one of the key cascades regulating embryogenesis and tissue
homeostasis; it has also been intimately associated with carcinogenesis. This pathway is …
homeostasis; it has also been intimately associated with carcinogenesis. This pathway is …