Classic studies of the factors that limit exercise revealed that exercise capacity is reduced at
high altitudes1 and in persons with cardiopulmonary disorders. 2 Because animal muscle …

This article reviews the classical basis on which dyspnea is identified and quantified. The
sensation or sensations of discomfort experienced during breathing are then viewed using a …

The rationale was as follows. The existence of a ventilatory boundary is an intuitively
reasonable explanation for exercise intolerance in chronic airflow limitation and is supported …

We studied the perception of breathlessness as a function of air flow obstruction in 45
asthmatic subjects using a category scaling technique. Air flow obstruction and …

The contribution of muscle strength to symptom intensity and work capacity was examined in
normal individuals and patients with cardiorespiratory disorders. Respiratory muscle …

Rationale: Extensive evidence in animal models supports a role for IL-13 in the pathobiology
of asthma. IMA-638 and IMA-026 are fully humanized IgG1 antibodies that bind to different …

We analyzed 28 thymic epithelial tumors (TETs) using next-generation sequencing and
identified a missense mutation (chromosome 7 c. 74146970T> A) in GTF2I at high frequency …

Background Checkpoint inhibitors have not been effective for prostate cancer as single
agents. Durvalumab is a human IgG1-K monoclonal antibody that targets programmed …

By the addition of externally added elastic loads at both functional residual capacity (FRC)
and increased lung volume, increased respiratory muscle effort, tension, and breathlessness …

Premature lactic acidosis during exercise in patients with chronic obstructive pulmonary
disease (COPD) may play a role in exercise intolerance. In this study, we evaluated whether …