Effects of 22 Months of Treatment with Inhaled Corticosteroids and/or Beta-2-Agonists on Lung Function, Airway Responsiveness, and Symptoms in Children with …

EJ DUIVERMAN, SJ POCOCK… - Am Rev Respir Dis, 1992 - atsjournals.org
In a randomized double-blind multicenter clinical study, 116children with asthma were
randomly assigned to treatment with an Inhaled beta-2-agonlst (salbutamol 0.2 mg) plus an …

Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma

KF Kerrebijn, EEM van Essen-Zandvliet… - Journal of allergy and …, 1987 - Elsevier
Airway inflammation is assumed to be an important determinant in increased bronchial
responsiveness (BR). We tested the hypothesis that treatment with an inhaled anti …

One year treatment with salmeterol compared with beclomethasone in children with asthma

AAPH Verberne, C Frost, RJ Roorda… - American Journal of …, 1997 - atsjournals.org
The aim of this study was to compare the effects of salmeterol and beclomethasone on lung
function and symptoms in children with mild to moderate asthma. Sixty-seven children not …

Addition of salmeterol versus doubling the dose of beclomethasone in children with asthma

AAPH Verberne, C Frost, EJ Duiverman… - American Journal of …, 1998 - atsjournals.org
Studies in adults revealed that addition of salmeterol to a moderate dose of inhaled
corticosteroid resulted in better symptom control and higher PEF compared with doubling …

Peak flow variation in childhood asthma: correlation with symptoms, airways obstruction, and hyperresponsiveness during long term treatment with inhaled …

PLP Brand, EJ Duiverman, HJ Waalkens… - Thorax, 1999 - thorax.bmj.com
BACKGROUND Guidelines for asthma management focus on treatment with inhaled
corticosteroids and on home recording of peak expiratory flow (PEF). The effect of …

Oxidative epithelial damage produces hyperresponsiveness of human peripheral airways.

AR Hulsmann, HR Raatgeep… - American journal of …, 1994 - atsjournals.org
The epithelium probably modulates airway smooth muscle responsiveness by producing
relaxing factors, by inactivating agonists, or by acting as a physical barrier. In isolated airway …

Forced oscillation technique. Reference values for resistance and reactance over a frequency spectrum of 2-26 Hz in healthy children aged 2.3-12.5 years.

EJ Duiverman, J Clement… - Bulletin Europeen de …, 1985 - europepmc.org
The forced pseudo-random noise oscillation technique is a method by which total respiratory
resistance (Rrs) and reactance (Xrs) can be measured simultaneously at various …

Control of airway caliber by autonomic nerves in asthma and in chronic obstructive pulmonary disease

JC De Jongste, RC Jongejan… - American Review of …, 1991 - atsjournals.org
Autonomic nerves can influence airway caliber via their effects on airway smooth muscle,
bronchial vessels, and mucous glands and may therefore contribute to airway narrowing in …

Central airways behave more stiffly during forced expiration in patients with asthma

HJL Brackel, OF Pedersen, PGH Mulder… - American journal of …, 2000 - atsjournals.org
Chronic inflammation and extracellular remodeling of the airway wall characterize asthma.
The purpose of this study was to examine whether these features cause a change in airway …

Growth of airways and air spaces in teenagers is related to sex but not to symptoms

PJ Merkus, GJ Borsboom, W Van Pelt… - Journal of Applied …, 1993 - journals.physiology.org
To determine growth patterns of the lung and airways in adolescents, we analyzed maximal
expiratory flow-volume curves, closing capacity, and residual volume. They were obtained …