Race and Genetic Ancestry in Medicine US health inequities won't be eliminated by
abandoning the use of race and ethnicity in research and clinical practice, since these …

Rationale: Independent replication of genetic associations in complex diseases, particularly
in whole-genome association studies, is critical to confirm the association. Objectives: A …

Background Asthma is a complex disease with both genetic and environmental causes.
Genome-wide association studies of asthma have mostly involved European populations …

Background The primary rescue medication to treat acute asthma exacerbation is the short-
acting β 2-adrenergic receptor agonist; however, there is variation in how well a patient …

We explored ancestry-related differences in the genetic architecture of whole-blood gene
expression using whole-genome and RNA sequencing data from 2,733 African Americans …

Background Secondhand smoke (SHS) exposures have been linked to asthma-related
outcomes but quantitative dose–responses using biomarkers of exposure have not been …

BACKGROUND: Polymorphisms in more than 100 genes have been associated with asthma
susceptibility, yet much of the heritability remains to be explained. Asthma disproportionately …

Type 2 T helper (TH2) cells are protective against parasitic worm infections but also
aggravate allergic inflammation. Although the role of dendritic cells (DCs) in TH2 cell …

Background Asthma is a chronic inflammatory disease with a strong genetic predisposition.
A major challenge for candidate gene association studies in asthma is the selection of …

Background: Maternal smoking during pregnancy is a risk factor for chronic disease later in
life and has been associated with variability of DNA methylation at specific cytosine …