Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia
Background Excessive use of empirical antibiotics is common in critically ill patients. Rapid
biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator …
biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator …
Pyogenic brain abscess and subdural empyema: presentation, management, and factors predicting outcome
JD Widdrington, H Bond, U Schwab, DA Price… - Infection, 2018 - Springer
Purpose To describe the presentation and management of bacterial brain abscess and
subdural empyema in adults treated at two tertiary centers. In addition, to identify factors that …
subdural empyema in adults treated at two tertiary centers. In addition, to identify factors that …
[HTML][HTML] Exposure of monocytic cells to lipopolysaccharide induces coordinated endotoxin tolerance, mitochondrial biogenesis, mitophagy, and antioxidant defenses
JD Widdrington, A Gomez-Duran, A Pyle… - Frontiers in …, 2018 - frontiersin.org
In order to limit the adverse effects of excessive inflammation, anti-inflammatory responses
are stimulated at an early stage of an infection, but during sepsis these can lead to …
are stimulated at an early stage of an infection, but during sepsis these can lead to …
Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis
EM Pinder, AJ Rostron, TP Hellyer… - Thorax, 2018 - thorax.bmj.com
Background Critically ill patients with impaired neutrophil phagocytosis have significantly
increased risk of nosocomial infection. Granulocyte-macrophage colony-stimulating factor …
increased risk of nosocomial infection. Granulocyte-macrophage colony-stimulating factor …
[HTML][HTML] Pyogenic spondylodiscitis: risk factors for adverse clinical outcome in routine clinical practice
JD Widdrington, I Emmerson, M Cullinan… - Medical …, 2018 - mdpi.com
We aimed to describe the clinical features and outcomes of pyogenic spondylodiscitis and to
identify factors associated with an unfavourable clinical outcome (defined as death …
identify factors associated with an unfavourable clinical outcome (defined as death …
Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness
J Scott, GJ Harris, EM Pinder, JG Macfarlane… - Journal of Allergy and …, 2016 - Elsevier
Background Neutrophils play a role in the pathogenesis of asthma, chronic obstructive
pulmonary disease, and pulmonary infection. Impaired neutrophil phagocytosis predicts …
pulmonary disease, and pulmonary infection. Impaired neutrophil phagocytosis predicts …
Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ
JD Widdrington, A Gomez-Duran, JS Steyn… - Journal of Allergy and …, 2017 - jacionline.org
Sepsis is a clinical syndrome with increasing incidence and mortality in which a systemic
inflammatory response is triggered by infection. The clinical outcome of sepsis is primarily …
inflammatory response is triggered by infection. The clinical outcome of sepsis is primarily …
Randomised Controlled Trial Of Granulocyte Macrophage Colony Stimulating Factor In Critically Ill Patients With Impaired Neutrophil Function
EM Pinder, AJ Rostron, TP Hellyer… - A104. CRITICAL …, 2016 - atsjournals.org
METHODS Critically ill patients, with impaired neutophil function (defined as< 50%
neutrophils ingesting 2 or more zymosan particles) were recruited from five intensive care …
neutrophils ingesting 2 or more zymosan particles) were recruited from five intensive care …