Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF
Rationale Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal of all
fibrotic conditions with no curative therapies. Common pathomechanisms between IPF and …
fibrotic conditions with no curative therapies. Common pathomechanisms between IPF and …
[HTML][HTML] The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
HV Woodcock, JD Eley, D Guillotin, M Platé… - Nature …, 2019 - nature.com
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix
deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The …
deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The …
An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices
MM Khan, D Poeckel, A Halavatyi… - European …, 2021 - Eur Respiratory Soc
Fibrosis can affect any organ, resulting in the loss of tissue architecture and function with
often life-threatening consequences. Pathologically, fibrosis is characterised by the …
often life-threatening consequences. Pathologically, fibrosis is characterised by the …
[HTML][HTML] A high content, phenotypic 'scar-in-a-jar'assay for rapid quantification of collagen fibrillogenesis using disease-derived pulmonary fibroblasts
Background Excessive extracellular matrix (ECM) deposition is a hallmark feature in fibrosis
and tissue remodelling diseases. Typically, mesenchymal cells will produce collagens under …
and tissue remodelling diseases. Typically, mesenchymal cells will produce collagens under …
Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
HV Woodcock, JD Eley, D Guillotin, M Platé… - Nature …, 2020 - nature.com
The original version of this article omitted from the author list the 19th author Andrew Fisher,
who is from the Newcastle Fibrosis Research Group, Newcastle University Translational and …
who is from the Newcastle Fibrosis Research Group, Newcastle University Translational and …
LSC-2017-mTOR-mediated cap-dependent translation is essential for human lung myofibroblast differentiation and collagen I synthesis
JD Eley, HV Woodcock, CB Nanthakumar, PF Mercer… - 2017 - Eur Respiratory Soc
Introduction: Aberrant control of translation has been recently described as a key regulator of
the idiopathic pulmonary fibrosis (IPF) myofibroblast phenotype. Mammalian target of …
the idiopathic pulmonary fibrosis (IPF) myofibroblast phenotype. Mammalian target of …