User profiles for "author:Jeremy K Nicholson"
Jeremy K NicholsonAustralian National Phenome Center, Murdoch University + Imperial College London Verified email at murdoch.edu.au Cited by 121484 |
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR …
The rapid evolution of drug discovery science, fuelled by combinatorial librarybased
synthesis programmes, has led to increased pressure on the drug safety evaluation process …
synthesis programmes, has led to increased pressure on the drug safety evaluation process …
Host-gut microbiota metabolic interactions
The composition and activity of the gut microbiota codevelop with the host from birth and is
subject to a complex interplay that depends on the host genome, nutrition, and life-style. The …
subject to a complex interplay that depends on the host genome, nutrition, and life-style. The …
Metabonomics: a platform for studying drug toxicity and gene function
JK Nicholson, J Connelly, JC Lindon… - Nature reviews Drug …, 2002 - nature.com
The later that a molecule or molecular class is lost from the drug development pipeline, the
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
Metabolic profiling, metabolomic and metabonomic studies mainly involve the
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …
Metabonomics
JK Nicholson, JC Lindon - Nature, 2008 - nature.com
Organisms often respond in complex and unpredictable ways to stimuli that cause disease
or injury. By measuring and mathematically modelling changes in the levels of products of …
or injury. By measuring and mathematically modelling changes in the levels of products of …
Human metabolic phenotype diversity and its association with diet and blood pressure
Metabolic phenotypes are the products of interactions among a variety of factors—dietary,
other lifestyle/environmental, gut microbial and genetic,,. We use a large-scale exploratory …
other lifestyle/environmental, gut microbial and genetic,,. We use a large-scale exploratory …
OPLS discriminant analysis: combining the strengths of PLS‐DA and SIMCA classification
The characteristics of the OPLS method have been investigated for the purpose of
discriminant analysis (OPLS‐DA). We demonstrate how class‐orthogonal variation can be …
discriminant analysis (OPLS‐DA). We demonstrate how class‐orthogonal variation can be …
Understanding'global'systems biology: metabonomics and the continuum of metabolism
JK Nicholson, ID Wilson - Nature Reviews Drug Discovery, 2003 - nature.com
To apply genomic knowledge effectively in drug discovery, mechanistic connectivities
between genetic variation and disease processes need to be established via systems …
between genetic variation and disease processes need to be established via systems …
Fat, fibre and cancer risk in African Americans and rural Africans
Rates of colon cancer are much higher in African Americans (65: 100,000) than in rural
South Africans (< 5: 100,000). The higher rates are associated with higher animal protein …
South Africans (< 5: 100,000). The higher rates are associated with higher animal protein …
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
Although a wide range of risk factors for coronary heart disease have been identified from
population studies, these measures, singly or in combination, are insufficiently powerful to …
population studies, these measures, singly or in combination, are insufficiently powerful to …