Experimental and quantitative imaging techniques in interstitial lung disease

ND Weatherley, JA Eaden, NJ Stewart, BJ Bartholmai… - Thorax, 2019 - thorax.bmj.com
Interstitial lung diseases (ILDs) are a heterogeneous group of conditions, with a wide and
complex variety of imaging features. Difficulty in monitoring, treating and exploring novel …

Lung MRI with hyperpolarised gases: current & future clinical perspectives

NJ Stewart, LJ Smith, HF Chan… - The British Journal of …, 2022 - academic.oup.com
The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT
remains the gold-standard for structural lung imaging in many clinical indications, technical …

Dissolved 129Xe lung MRI with four‐echo 3D radial spectroscopic imaging: Quantification of regional gas transfer in idiopathic pulmonary fibrosis

GJ Collier, JA Eaden, PJC Hughes… - Magnetic …, 2021 - Wiley Online Library
Purpose Imaging of the different resonances of dissolved hyperpolarized xenon‐129
(129Xe) in the lung is performed using a four‐echo flyback 3D radial spectroscopic imaging …

[HTML][HTML] Large-scale investigation of deep learning approaches for ventilated lung segmentation using multi-nuclear hyperpolarized gas MRI

JR Astley, AM Biancardi, PJC Hughes, H Marshall… - Scientific Reports, 2022 - nature.com
Respiratory diseases are leading causes of mortality and morbidity worldwide. Pulmonary
imaging is an essential component of the diagnosis, treatment planning, monitoring, and …

A Dual‐Channel Deep Learning Approach for Lung Cavity Estimation From Hyperpolarized Gas and Proton MRI

JR Astley, AM Biancardi, H Marshall… - Journal of Magnetic …, 2023 - Wiley Online Library
Background Hyperpolarized gas MRI can quantify regional lung ventilation via biomarkers,
including the ventilation defect percentage (VDP). VDP is computed from segmentations …

[HTML][HTML] Longitudinal lung function assessment of patients hospitalized with COVID-19 Using 1H and 129Xe lung MRI

LC Saunders, GJ Collier, HF Chan, PJC Hughes… - Chest, 2023 - Elsevier
Background Microvascular abnormalities and impaired gas transfer have been observed in
patients with COVID-19. The progression of pulmonary changes in these patients remains …

Quantification of pulmonary perfusion in idiopathic pulmonary fibrosis with first pass dynamic contrast-enhanced perfusion MRI

ND Weatherley, JA Eaden, PJC Hughes, M Austin… - Thorax, 2021 - thorax.bmj.com
Introduction Idiopathic pulmonary fibrosis (IPF) is a fatal disease of lung scarring. Many
patients later develop raised pulmonary vascular pressures, sometimes disproportionate to …

[HTML][HTML] Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen enhanced 1H MRI

M Tibiletti, JA Eaden, JH Naish, PJC Hughes… - Magnetic Resonance …, 2023 - Elsevier
Purpose To compare imaging biomarkers from hyperpolarised 129 Xe ventilation MRI and
dynamic oxygen-enhanced MRI (OE-MRI) with standard pulmonary function tests (PFT) in …

[HTML][HTML] Real world experience of response to pirfenidone in patients with idiopathic pulmonary fibrosis: a two centre retrospective study

JA Eaden, CM Barber, SA Renshaw… - … Vasculitis, and Diffuse …, 2020 - ncbi.nlm.nih.gov
Methods: Using the rate of decline in FVC% predicted in the 12 months prior to pirfenidone,
patients were stratified into slow (< 5%) or rapid (≥ 5%) decliner groups. Comparisons in …

Free breathing lung T1 mapping using image registration in patients with idiopathic pulmonary fibrosis

LC Saunders, JA Eaden, SM Bianchi… - Magnetic …, 2020 - Wiley Online Library
Purpose To assess the use of image registration for correcting respiratory motion in free
breathing lung T1 mapping acquisition in patients with idiopathic pulmonary fibrosis (IPF) …