Intravenous tranexamic acid (TXA) reduces death because of bleeding in patients with
trauma and postpartum haemorrhage. However, in some settings intravenous injection is not …

Understanding the dose–concentration–effect relationship is a fundamental component of
clinical pharmacology. Interpreting data arising from observations of this relationship …

Background The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral
antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the …

Optimising the dosing of medicines for neonates and children remains a challenge. The
importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised …

Many medicines prescribed for children are unlicensed. Solid dosage forms present
problems as children have difficulty swallowing whole tablets or capsules. When medicines …

Background Intranasal dexmedetomidine produces safe, effective sedation in children and
adults. It may be administered by drops from a syringe or by nasal mucosal atomisation …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

There is little data available to guide amoxicillin-clavulanic acid dosing in critically ill
children. The primary objective of this study was to investigate the pharmacokinetics of both …

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and
conduct of clinical pharmacology research in children. During drug development, PKPD …

Inadequate dose selection for confirmatory trials is currently still one of the most challenging
issues in drug development, as illustrated by high rates of late‐stage attritions in clinical …