[HTML][HTML] A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
Background The outcome of childhood asthma in adults has been described in high-risk
cohorts, but few population-based studies have reported the risk factors for persistence and …
cohorts, but few population-based studies have reported the risk factors for persistence and …
[HTML][HTML] Use of exhaled nitric oxide measurements to guide treatment in chronic asthma
AD Smith, JO Cowan, KP Brassett… - … England Journal of …, 2005 - Mass Medical Soc
Background International guidelines for the treatment of asthma recommend adjusting the
dose of inhaled corticosteroids on the basis of symptoms, bronchodilator requirements, and …
dose of inhaled corticosteroids on the basis of symptoms, bronchodilator requirements, and …
Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study
Background Breastfeeding is widely advocated to reduce risk of atopy and asthma, but the
evidence for such an effect is conflicting. We aimed to assess long-term outcomes of asthma …
evidence for such an effect is conflicting. We aimed to assess long-term outcomes of asthma …
Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests
AD Smith, JO Cowan, S Filsell… - American journal of …, 2004 - atsjournals.org
International guidelines recommend a range of clinical tests to confirm the diagnosis of
asthma. These focus largely on identifying variable airflow obstruction and responses to …
asthma. These focus largely on identifying variable airflow obstruction and responses to …
The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control
SL Jones, J Kittelson, JO Cowan… - American journal of …, 2001 - atsjournals.org
Exhaled nitric oxide (eNO) levels are increased in untreated or unstable asthma and
measurements can be made easily. Our aim was to assess the usefulness of eNO for …
measurements can be made easily. Our aim was to assess the usefulness of eNO for …
Exhaled nitric oxide: a predictor of steroid response
AD Smith, JO Cowan, KP Brassett, S Filsell… - American journal of …, 2005 - atsjournals.org
Rationale: The initial management of patients who present with persistent respiratory
symptoms includes recognizing those with the potential to benefit from inhaled steroid …
symptoms includes recognizing those with the potential to benefit from inhaled steroid …
Effects of steroid therapy on inflammatory cell subtypes in asthma
DC Cowan, JO Cowan, R Palmay, A Williamson… - Thorax, 2010 - thorax.bmj.com
Rationale Airway inflammation in asthma is heterogeneous with different phenotypes. The
inflammatory cell phenotype is modified by corticosteroids and smoking. Steroid therapy is …
inflammatory cell phenotype is modified by corticosteroids and smoking. Steroid therapy is …
Sex differences in the relation between body mass index and asthma and atopy in a birth cohort
Rationale: Several studies have identified an association between asthma and obesity in
women. It remains unclear if this association is due to genuine asthma or to symptoms …
women. It remains unclear if this association is due to genuine asthma or to symptoms …
Risk Factors for Airway Remodeling in Asthma Manifested by a Low Postbronchodilator FEV1/Vital Capacity Ratio: A Longitudinal Population Study from Childhood to …
F Rasmussen, DR Taylor, EM Flannery… - American Journal of …, 2002 - atsjournals.org
Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of
childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was …
childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was …
Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
Background Airway inflammation is associated with asthma exacerbation risk, treatment
response, and disease mechanisms. Objective This study aimed to identify and validate a …
response, and disease mechanisms. Objective This study aimed to identify and validate a …