[HTML][HTML] A longitudinal, population-based, cohort study of childhood asthma followed to adulthood

MR Sears, JM Greene, AR Willan… - … England Journal of …, 2003 - Mass Medical Soc
Background The outcome of childhood asthma in adults has been described in high-risk
cohorts, but few population-based studies have reported the risk factors for persistence and …

[HTML][HTML] Use of exhaled nitric oxide measurements to guide treatment in chronic asthma

AD Smith, JO Cowan, KP Brassett… - … England Journal of …, 2005 - Mass Medical Soc
Background International guidelines for the treatment of asthma recommend adjusting the
dose of inhaled corticosteroids on the basis of symptoms, bronchodilator requirements, and …

Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study

MR Sears, JM Greene, AR Willan, DR Taylor… - The Lancet, 2002 - thelancet.com
Background Breastfeeding is widely advocated to reduce risk of atopy and asthma, but the
evidence for such an effect is conflicting. We aimed to assess long-term outcomes of asthma …

Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests

AD Smith, JO Cowan, S Filsell… - American journal of …, 2004 - atsjournals.org
International guidelines recommend a range of clinical tests to confirm the diagnosis of
asthma. These focus largely on identifying variable airflow obstruction and responses to …

The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control

SL Jones, J Kittelson, JO Cowan… - American journal of …, 2001 - atsjournals.org
Exhaled nitric oxide (eNO) levels are increased in untreated or unstable asthma and
measurements can be made easily. Our aim was to assess the usefulness of eNO for …

Exhaled nitric oxide: a predictor of steroid response

AD Smith, JO Cowan, KP Brassett, S Filsell… - American journal of …, 2005 - atsjournals.org
Rationale: The initial management of patients who present with persistent respiratory
symptoms includes recognizing those with the potential to benefit from inhaled steroid …

Effects of steroid therapy on inflammatory cell subtypes in asthma

DC Cowan, JO Cowan, R Palmay, A Williamson… - Thorax, 2010 - thorax.bmj.com
Rationale Airway inflammation in asthma is heterogeneous with different phenotypes. The
inflammatory cell phenotype is modified by corticosteroids and smoking. Steroid therapy is …

Sex differences in the relation between body mass index and asthma and atopy in a birth cohort

RJ Hancox, BJ Milne, R Poulton, DR Taylor… - American journal of …, 2005 - atsjournals.org
Rationale: Several studies have identified an association between asthma and obesity in
women. It remains unclear if this association is due to genuine asthma or to symptoms …

Risk Factors for Airway Remodeling in Asthma Manifested by a Low Postbronchodilator FEV1/Vital Capacity Ratio: A Longitudinal Population Study from Childhood to …

F Rasmussen, DR Taylor, EM Flannery… - American Journal of …, 2002 - atsjournals.org
Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of
childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was …

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

KJ Baines, JL Simpson, LG Wood, RJ Scott… - Journal of allergy and …, 2014 - Elsevier
Background Airway inflammation is associated with asthma exacerbation risk, treatment
response, and disease mechanisms. Objective This study aimed to identify and validate a …