User profiles for "author:J K Field"

John K Field

Clinical Professor of Molecular Oncology, The University of Liverpool, UK
Verified email at liverpool.ac.uk
Cited by 35819

European position statement on lung cancer screening

M Oudkerk, A Devaraj, R Vliegenthart… - The Lancet …, 2017 - thelancet.com
Lung cancer screening with low-dose CT can save lives. This European Union (EU) position
statement presents the available evidence and the major issues that need to be addressed …

Lung cancer LDCT screening and mortality reduction—evidence, pitfalls and future perspectives

M Oudkerk, SY Liu, MA Heuvelmans… - Nature reviews Clinical …, 2021 - nature.com
In the past decade, the introduction of molecularly targeted agents and immune-checkpoint
inhibitors has led to improved survival outcomes for patients with advanced-stage lung …

The OncoArray Consortium: a network for understanding the genetic architecture of common cancers

CI Amos, J Dennis, Z Wang, J Byun… - … , biomarkers & prevention, 2017 - AACR
Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

Comprehensive genomic profiles of small cell lung cancer

J George, JS Lim, SJ Jang, Y Cun, L Ozretić, G Kong… - Nature, 2015 - nature.com
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the
deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation …

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

RJ Hung, JD McKay, V Gaborieau, P Boffetta… - Nature, 2008 - nature.com
Lung cancer is the most common cause of cancer death worldwide, with over one million
cases annually. To identify genetic factors that modify disease risk, we conducted a genome …

[PDF][PDF] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

MT Landi, N Chatterjee, K Yu, LR Goldin… - The american journal of …, 2009 - cell.com
Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not …

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

M Ehrich, MR Nelson, P Stanssens… - Proceedings of the …, 2005 - National Acad Sciences
Methylation is one of the major epigenetic processes pivotal to our understanding of
carcinogenesis. It is now widely accepted that there is a relationship between DNA …

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

JD McKay, RJ Hung, Y Han, X Zong… - Nature …, 2017 - nature.com
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …

[HTML][HTML] The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors …

MT Jaklitsch, FL Jacobson, JHM Austin, JK Field… - The Journal of thoracic …, 2012 - Elsevier
OBJECTIVE: Lung cancer is the leading cause of cancer death in North America. Low-dose
computed tomography screening can reduce lung cancer–specific mortality by 20 …

UK Lung Cancer RCT Pilot Screening Trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening

JK Field, SW Duffy, DR Baldwin, DK Whynes… - Thorax, 2016 - thorax.bmj.com
Background Lung cancer screening using low-dose CT (LDCT) was shown to reduce lung
cancer mortality by 20% in the National Lung Screening Trial. Methods The pilot UK Lung …