Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors

H van de Waterbeemd, G Camenisch… - Journal of drug …, 1998 - Taylor & Francis
The influence of physicochemical properties, including lipophilicity, H-bonding capacity and
molecular size and shape descriptors on brain uptake has been investigated using a …

[HTML][HTML] Influenza forecasting in human populations: a scoping review

JP Chretien, D George, J Shaman, RA Chitale… - PloS one, 2014 - journals.plos.org
Forecasts of influenza activity in human populations could help guide key preparedness
tasks. We conducted a scoping review to characterize these methodological approaches …

[HTML][HTML] Beyond traditional surveillance: applying syndromic surveillance to developing settings–opportunities and challenges

L May, JP Chretien, JA Pavlin - BMC Public Health, 2009 - Springer
Background All countries need effective disease surveillance systems for early detection of
outbreaks. The revised International Health Regulations [IHR], which entered into force for …

Online posting of unprofessional content by medical students

KC Chretien, SR Greysen, JP Chretien, T Kind - Jama, 2009 - jamanetwork.com
Context Web 2.0 applications, such as social networking sites, are creating new challenges
for medical professionalism. The scope of this problem in undergraduate medical education …

Prediction of a Rift Valley fever outbreak

A Anyamba, JP Chretien, J Small… - Proceedings of the …, 2009 - National Acad Sciences
El Niño/Southern Oscillation related climate anomalies were analyzed by using a
combination of satellite measurements of elevated sea-surface temperatures and …

Epidemiology of weaning outcome according to a new definition. The WIND study

G Béduneau, T Pham, F Schortgen… - American journal of …, 2017 - atsjournals.org
Rationale: The weaning process concerns all patients receiving mechanical ventilation. A
previous classification into simple, prolonged, and difficult weaning ignored weaning failure …

[PDF][PDF] Drought-associated chikungunya emergence along coastal East Africa

JP Chretien, A Anyamba, SA Bedno, RF Breiman… - 2007 - academia.edu
Epidemics of chikungunya fever, an Aedes spp.-borne viral disease, affected hundreds of
thousands of people in western Indian Ocean islands and India during 2005–2006. The …

[HTML][HTML] A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study

C Guerin, P Beuret, JM Constantin, G Bellani… - Intensive care …, 2018 - Springer
Introduction While prone positioning (PP) has been shown to improve patient survival in
moderate to severe acute respiratory distress syndrome (ARDS) patients, the rate of …

Pleural effusion: laboratory tests in 300 cases.

A Hirsch, P Ruffie, M Nebut, J Bignon, J Chretien - Thorax, 1979 - thorax.bmj.com
The cause of pleural effusion was studied in 300 consecutive patients by clinical
examination and laboratory tests. The three most common causes were found to be cancer …

[HTML][HTML] Differential susceptibility to hypertension is due to selection during the out-of-Africa expansion

JH Young, YPC Chang, JDO Kim, JP Chretien… - PLoS …, 2005 - journals.plos.org
Hypertension is a leading cause of stroke, heart disease, and kidney failure. The genetic
basis of blood pressure variation is largely unknown but is likely to involve genes that …